Oscillations in reverse triiodothyronine levels in serum of healthy infants aged 0 to 130 hours.
Oscillations in reverse triiodothyronine levels in serum of healthy infants aged 0 to 130 hours.
复制标题
0 至 130 小时健康婴儿血清中反向三碘甲状腺原氨酸水平的波动。
DOI：
--
复制
发表时间：
1979
影响因子：
5.8
通讯作者：
D. Fisher
中科院分区：
文献类型：
--
作者：
B. Bernard;T. H. Oddie;A. Klein;D. Fisher
本文用放射免疫分析法测定了273例0--130 h正常婴儿血清rT_3。平均rT 3水平对年龄的曲线呈多指数形状，并显示叠加振荡，周期约为16小时，与先前在同一组受试者中发现的T4、T3和TSH曲线相似（J Clin Endocrinol Metab 47：61，1978）。rT 3与T4的浓度比保持大致恒定，在3- 130 h的年龄范围内平均值为0.016。这些观察结果表明，在新生儿血清中的rT 3水平的变化在生命的头几天在很大程度上是由T4底物浓度的变化负责。
rT3 was measured by RIA in sera from 273 normal healthy infants between 0--130 h of age. The curve for the mean rT3 level plotted against age was polyexponential in shape and showed superimposed oscillations with a period of about 16 h, similar to the curves for T4, T3, and TSH previously found for the same group of subjects (J Clin Endocrinol Metab 47: 61, 1978). The ratio of concentrations of rT3 to T4 remained approximately constant, with a mean value of 0.016 over the age range of 3--130 h. These observations suggest that the variations in rT3 levels in newborn serum during the first few days of life are largely accountable by variations in T4 substrate concentrations.