Centrins, a novel group of Ca2+-binding proteins in vertebrate photoreceptor cells.
Centrins, a novel group of Ca2+-binding proteins in vertebrate photoreceptor cells.
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DOI：
10.1007/978-1-4615-0121-3_10
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发表时间：
2002
影响因子：
--
通讯作者：
U. Wolfrum;A. Giessl;A. Pulvermüller
中科院分区：
文献类型：
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作者：
U. Wolfrum;A. Giessl;A. Pulvermüller
细胞内Ca 2+浓度的变化直接影响视觉信号转导级联，或更经常地通过Ca 2+结合蛋白间接影响视觉信号转导级联。在这里，我们回顾了最近的研究结果中心蛋白在感光细胞的哺乳动物视网膜。中心蛋白是Ca 2+结合蛋白EF-hand超家族的一个高度保守的亚组，通常与中心体相关结构相关。在脊椎动物的感光细胞中，中心蛋白也是连接纤毛的主要成分，连接光敏感的外节与生物合成活性的内节隔室。最近的研究表明，钙激活的中心蛋白形成复合物的视觉G蛋白转导在感光细胞。这种依赖于Ca 2+的G蛋白与中心蛋白的组装是感觉细胞中信号蛋白供应的一个新方面，并且是分子易位和信号转导之间的潜在联系。
Changes in the intracellular Ca2+-concentration affect the visual signal transduction cascade directly or more often indirectly through Ca2+-binding proteins. Here we review recent findings on centrins in photoreceptor cells of the mammalian retina. Centrins are members of a highly conserved subgroup of the EF-hand super-family of Ca2tbinding proteins commonly associated with centrosome-related structures. In vertebrate photoreceptor cells, centrins are also prominent components in the connecting cilium linking the light sensitive outer segment with the biosynthetically active inner segment compartment. Recent findings demonstrate that Ca2+-activated centrin forms a complex with the visual G-protein transducin in photoreceptor cells. This Ca2+-dependent assembly of G-proteins with centrin is a novel aspect of the supply of signaling proteins in sensory cells, and a potential link between molecular translocations and signal transduction in general.