A meta-analysis of the efficacy of anodal transcranial direct current stimulation for upper limb motor recovery in stroke survivors
A meta-analysis of the efficacy of anodal transcranial direct current stimulation for upper limb motor recovery in stroke survivors
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DOI：
10.1016/j.jht.2012.07.002
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发表时间：
2013-04-01
影响因子：
2
通讯作者：
Guilkey, Karen
中科院分区：
文献类型：
--
作者：
Butler, Andrew J.;Shuster, Margaret;Guilkey, Karen
研究设计：系统综述和荟萃分析。引言：关于阳极经颅直流电刺激（a-tDCS）效果的既往综述表明，a-tDCS对健康个体的皮质运动兴奋性和运动功能有效，但对卒中受试者无显著影响。目的：总结和评价a-tDCS治疗卒中后上肢运动障碍疗效的证据。方法：一项荟萃分析的随机对照试验，比较了a-tDCS与安慰剂和从basel.Results变化：汇总分析显示，有利于a-tDCS的评分显着增加（标准平均差[SMD] = 0.40，95%置信区间[CI] = 0.10-0.70，p = 0.010，与基线相比）。a-tDCS和假手术组之间观察到类似的效果（SMD = 0.49，95%CI = 0.18-0.81，p = 0.005）。结论：8项随机安慰剂对照试验的荟萃分析提供了进一步的证据，表明a-tDCS可能有益于慢性卒中患者的偏瘫上肢运动功能。爱思唯尔公司出版代表爱思唯尔公司旗下的汉利和贝尔福斯公司。
Study Design: Systematic review and meta-analysis.Introduction: Prior reviews on the effects of anodal transcranial direct current stimulation (a-tDCS) have shown the effectiveness of a-tDCS on corticomotor excitability and motor function in healthy individuals but nonsignificant effect in subjects with stroke.Purpose: To summarize and evaluate the evidence for the efficacy of a-tDCS in the treatment of upper limb motor impairment after stroke.Methods: A meta-analysis of randomized controlled trials that compared a-tDCS with placebo and change from baseline.Results: A pooled analysis showed a significant increase in scores in favor of a-tDCS (standard mean difference [SMD] = 0.40, 95% confidence interval [CI] = 0.10-0.70, p = 0.010, compared with baseline). A similar effect was observed between a-tDCS and sham (SMD = 0.49, 95% CI = 0.18-0.81, p = 0.005).Conclusion: This meta-analysis of eight randomized placebo-controlled trials provides further evidence that a-tDCS may benefit motor function of the paretic upper limb in patients suffering from chronic stroke.Level of Evidence: Level la. Published by Elsevier Inc. on behalf of Hanley & Belfus, an imprint of Elsevier Inc.