Perinatal diet influences health and survival in a mouse model of leukemia.
Perinatal diet influences health and survival in a mouse model of leukemia.
复制标题
围产期饮食影响白血病小鼠模型的健康和生存。
DOI：
10.1007/s11357-020-00199-9
复制
发表时间：
2020
期刊：
影响因子：
5.6
通讯作者：
deCabo,Rafael
中科院分区：
文献类型：
--
作者：
Palliyaguru,DushaniL;Rudderow,AnnamariaL;Sossong,AlexM;Lewis,KaitlynN;Younts,Caitlin;Pearson,KevinJ;Bernier,Michel;deCabo,Rafael
本研究的目的是确定围产期母体饮食对后代健康和存活的作用。使用AKR/J小鼠（一种描述为易患白血病的模型），其中雌性小鼠在与SD喂养的雄性小鼠交配时维持标准饮食（SD）、高蔗糖饮食、西方饮食或热量限制（CR）。体重、妊娠率、窝仔数和窝仔存活率被用作成功妊娠和幼仔健康的标志物。数据表明，母亲的饮食有显着的影响，窝仔数，早期幼崽的生存，早期幼崽的体重。随着幼崽的成熟，它们各自的母体饮食构成是成年代谢健康和生存的预测因子。总的来说，这些结果表明，围产期母亲的饮食是一个重要的决定因素的健康和生存的后代，这些影响持续到成年期，与寿命密切相关。
The goal of the current study was to determine the role of maternal diet in the perinatal period on the health and survival of the offspring. AKR/J mice, a model described to be susceptible to leukemia development, was used where females were maintained on either standard diet (SD), high sucrose diet, Western diet, or calorie restriction (CR) as they were mated with SD-fed males. Body weights, pregnancy rates, litter size, and litter survival were used as markers of successful pregnancy and pup health. Data indicated that maternal diet had significant effects on litter size, early pup survival, and early pup body weights. As pups matured, the makeup of their respective maternal diet was a predictor of adult metabolic health and survival. Overall, these results suggest that perinatal maternal diet is an important determinant of the health and survival of the offspring and that these effects continue well into adulthood, strongly correlating with lifespan.