EXPRESSION OF MAGE-A4 AND MAGE-C1 TUMOR-ASSOCIATED ANTIGEN IN BENIGN AND MALIGNANT THYROID DISEASES
EXPRESSION OF MAGE-A4 AND MAGE-C1 TUMOR-ASSOCIATED ANTIGEN IN BENIGN AND MALIGNANT THYROID DISEASES
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DOI：
10.1002/hed.21616
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发表时间：
2011-10-01
影响因子：
2.9
通讯作者：
Zago, Marco Antonio
中科院分区：
文献类型：
--
作者：
Melo, Daniel Hardy;Martins Mamede, Rui Celso;Zago, Marco Antonio
Background. A subset of thyroid tumors characterized by a follicular growth pattern can represent a serious diagnosis. Immunohistochemistry and molecular pathology for genetic profiling have been used in an attempt to resolve some of these issues.Methods. Tumor tissue samples of thyroid were obtained from 70 patients who underwent surgical therapy. They were divided into 4 groups: 20 adenomatous goiters, 10 follicular adenomas, 24 papillary carcinomas, and 16 follicular carcinomas. Immunohistochemical analysis was carried out using antibodies for MAGE-A4 (melanoma antigen-encoding gene A4) and MAGE-C1 (melanoma antigen-encoding gene C1).Results. Standard histologic analysis and immunohistochemistry analysis of MAGE-A4 and MAGE-C1 expression were performed in all patients. The antigens examined were not expressed in any of the tissues.Conclusions. The malignant degeneration of normal tissues is a multifactorial process, varying considerably both among tumor types and among individual patients. The present study showed that there was no immunolabeling of the MAGE-A4 and MAGE-C1 antigens. (C) 2011 Wiley Periodicals, Inc. Head Neck 33: 1426-1432, 2011
