PCBs and dioxin-like compounds in plasma of adult Inuit living in Nunavik (Arctic Quebec)
PCBs and dioxin-like compounds in plasma of adult Inuit living in Nunavik (Arctic Quebec)
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DOI：
10.1016/s0045-6535(97)00442-6
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发表时间：
1997-03-01
期刊：
影响因子：
8.8
通讯作者：
Lebel, G
中科院分区：
文献类型：
--
作者：
Ayotte, P;Dewailly, E;Lebel, G
居住在北极地区的因纽特人由于其传统饮食中含有大量海洋哺乳动物脂肪，因此经常接触到有机氯。最近，来自努纳维克（北极魁北克）的499名因纽特成年人参加了一项大型健康调查，捐献了一份血样，用于有机氯和重金属分析。形成了20份合并血浆样本，每份样本由来自相同年龄组、性别和居住地区的个体样本组成，以进行二恶英样化合物测定。多氯联苯和二恶英类化合物（后者以2，3，7，8-四氯二苯并对二恶英毒性当量表示）的平均总浓度分别为4.1毫克/千克脂质和184.2纳克/千克脂质，而来自南魁北克的三个对照合并血浆样本的平均总浓度分别为0.13毫克/千克脂质和26.1纳克/千克脂质。总的PCBs和二恶英类化合物的浓度有很强的相关性（r = 0.98; p < 0.0001），随着年龄的增长，男性的浓度高于女性。虽然多氯联苯和二恶英类化合物的体内负荷量接近于对实验室动物造成不良健康影响的负荷量，但以海鲜为主的饮食带来的好处仍然超过了假设的健康风险。(C)1997 Elsevier Science Ltd.
Inuit people residing in the Arctic are unusually exposed to organochlorines through their traditional diet which includes large quantities of sea mammal fat. Recently, 499 Inuit adults from Nunavik (Arctic Quebec) participated in a large health survey acid donated a blood sample for organochlorine and heavy metal analysis. Twenty pooled plasma samples were formed, each made of individual samples from the same age group, sex, and region of residence, to allow for dioxin-like compound determination. The mean total concentration of PCBs and dioxin-like compounds (the latter expressed in 2,3,7,8-TCDD toxic equivalents) were respectively 4.1 mg/kg lipids and 184.2 ng/kg lipids, compared to 0.13 mg/kg lipids and 26.1 ng/kg lipids for three control pooled plasma samples from Southern Quebec. Total PCBs and dioxin-like compound concentrations were strongly correlated (r = 0.98; p < 0.0001), increased with age acid were greater in men than in women. Although the body burdens of PCBs and dioxin-like compounds are close to those which induced adverse health effects in laboratory animals, dietary benefits from the sea-food based diet still outweigh the hypothetical health risks. (C) 1997 Elsevier Science Ltd.