Design and initiation of a study to assess the direct and indirect effects of influenza vaccine given to children in rural India.
Design and initiation of a study to assess the direct and indirect effects of influenza vaccine given to children in rural India.
复制标题
设计并启动一项研究，以评估印度农村儿童接种流感疫苗的直接和间接影响。
DOI：
10.1016/j.vaccine.2012.06.002
复制
发表时间：
2012
期刊：
影响因子：
5.5
通讯作者：
Broor,Shobha
中科院分区：
文献类型：
--
作者：
Sullender,Wayne;Fowler,Karen;Krishnan,Anand;Gupta,Vivek;Moulton,LawrenceH;Lafond,Kathryn;Widdowson,Marc-Alain;Lal,RenuB;Broor,Shobha
众所周知，引入 Hib 疫苗可对降低 5 岁以下儿童的发病率和死亡率产生积极影响。然而，将这种疫苗纳入国家 EPI 确实需要付出高昂的代价，这对于非全球疫苗和免疫联盟资助的国家尤其重要。某些患者群体的反应复合减少以及可能的加强剂量指示进一步影响成本效益分析。尽管存在这些问题，南非自 2009 年以来仍以组合疫苗 Pentaxim® 的形式提供 Hib 疫苗，作为国家 EPI 的一部分，该疫苗将 Hib 与白喉、破伤风、无细胞百日咳 (DTP) 和脊髓灰质炎结合起来。在此之前，使用了另一种含有 Hib 和 DTP 的组合疫苗。这随后导致引入后侵袭性 Hib 疾病的显着减少，因此在很大程度上证明了使用的合理性。
Introduction of Hib vaccine is known to positively impact on reduction of both morbidity and mortality in children less than 5 years of age. Incorporation of this vaccine into a National EPI, however, does come at a significant cost, which is especially important in non-GAVI funded countries. Compounded reduction in response in certain patient populations and possible indication of booster doses further impacts on cost-benefit analyses. Despite these issues, South Africa has supplied Hib vaccine as part of the National EPI in the form of a combination vaccine, Pentaxim®, which combines Hib with Diphtheria, Tetanus, acellular Pertussis (DTP) and Poliomyelitis since 2009. Prior to this, another combination vaccine was utilized containing Hib and DTP. This has subsequently lead to a significant reduction in invasive Hib disease post-introduction, therefore largely justifying utilization.