Developmental characteristics of brain catecholamines and tyrosine hydroxylase in the rat: effects of 6‐hydroxydopamine
Developmental characteristics of brain catecholamines and tyrosine hydroxylase in the rat: effects of 6‐hydroxydopamine
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大鼠脑儿茶酚胺和酪氨酸羟化酶的发育特征：6-羟基多巴胺的影响
DOI：
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发表时间：
1972
影响因子：
7.3
通讯作者：
T. D. Traylor
中科院分区：
文献类型：
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作者：
G. Breese;T. D. Traylor
1脑内去甲肾上腺素、多巴胺和酪氨酸羟化酶在出生前几天就已在大鼠脑内发现，并逐渐增加，直至成年。这些物质生长最快的时期似乎发生在7至18天之间。2脑池内给予7日龄大鼠6-羟基多巴胺，72小时后去甲肾上腺素、多巴胺和酪氨酸羟化酶的浓度降低。3在7或14日龄时接受6-羟基多巴胺的大鼠中，去甲肾上腺素、多巴胺或酪氨酸羟化酶的浓度在成年后测定时仍显著降低，表明给予该化合物后纤维未继续发育。第7天处理的大鼠也显示心脏中去甲肾上腺素浓度降低。4在第7天注射6-羟基多巴胺的大鼠体重减轻，一些器官重量也减轻。在14日龄时接受该药物的动物中未观察到这种生长缺陷。5在第7天给予接受6-羟基多巴胺的大鼠绵羊生长激素，没有逆转这些动物的生长缺陷。
1 Brain noradrenaline, dopamine and tyrosine hydroxylase were found in rat brain a few days before birth and increased progressively until reaching adult values. The most rapid period of growth for these substances seemed to occur between 7 and 18 days. 2 The intracisternal administration of 6‐hydroxydopamine to rats 7 days of age reduced concentrations of noradrenaline, dopamine, and tyrosine hydroxylase by 72 hours. 3 The concentrations of noradrenaline, dopamine or tyrosine hydroxylase in rats that received 6‐hydroxydopamine at 7 or 14 days of age remained markedly reduced when determined at adulthood, indicating that fibres did not continue to develop after the administration of this compound. The rats treated at 7 days also showed diminished concentrations of noradrenaline in heart. 4 Rats injected with 6‐hydroxydopamine at 7 days had reduced body weight as well as a reduction of some organ weights. This growth deficit was not observed in animals that received this drug at 14 days of age. 5 The administration of ovine growth hormone to rats that received 6‐hydroxydopamine at 7 days did not reverse the growth deficiency in these animals.