Glutaminolysis as a target for cancer therapy.
Glutaminolysis as a target for cancer therapy.
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DOI：
10.1038/onc.2015.447
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发表时间：
2016-07-14
期刊：
影响因子：
8
通讯作者：
Kang S
中科院分区：
文献类型：
--
作者：
Jin L;Alesi GN;Kang S
癌细胞显示出改变的代谢回路，该回路直接受到致癌突变和肿瘤抑制因子缺失的调节。越来越多的证据表明，癌细胞中改变的谷氨酰胺代谢在支持大分子生物合成、调节信号传导途径和维持氧化还原稳态方面具有关键作用，所有这些都有助于癌细胞增殖和存活。因此，干预这些代谢过程可以提供改善癌症治疗的新方法。这篇综述总结了目前的研究结果，在人类癌症中的作用，并提供了一个更新的小分子抑制剂的发展，以靶向阿糖胞苷的癌症治疗。
Cancer cells display an altered metabolic circuitry that is directly regulated by oncogenic mutations and loss of tumor suppressors. Mounting evidence indicates that altered glutamine metabolism in cancer cells has critical roles in supporting macromolecule biosynthesis, regulating signaling pathways, and maintaining redox homeostasis, all of which contribute to cancer cell proliferation and survival. Thus, intervention in these metabolic processes could provide novel approaches to improve cancer treatment. This review summarizes current findings on the role of glutaminolytic enzymes in human cancers and provides an update on the development of small molecule inhibitors to target glutaminolysis for cancer therapy.