Epigenetic regulation of centromere formation and kinetochore function
Epigenetic regulation of centromere formation and kinetochore function
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DOI：
10.1139/o06-080
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发表时间：
2006-08-01
影响因子：
2.9
通讯作者：
Hendzel, Michael J.
中科院分区：
文献类型：
--
作者：
Heit, Ryan;Underhill, D. Alan;Hendzel, Michael J.
在对基因组调控的分子基础了解越来越详细的过程中，我们对分子生物化学与细胞内染色质结构的关系仍然只是模糊的认识。着丝粒是每条染色体的一个结构和功能上独特的区域，它提供了一个例子，在这个例子中，分子的理解远远超过了对染色体尺度上出现的结构和功能关系的理解。着丝粒位于染色体的初级收缩处。在进入有丝分裂过程中，着丝粒指定着丝点的组装位置，着丝点与微管结合，使染色体能够运输到子细胞中。从染色质功能的结构机制出发，综述了表观遗传学对着丝粒分子组织和功能的影响。
In the midst of an increasingly detailed understanding of the molecular basis of genome regulation, we still only vaguely understand the relationship between molecular biochemistry and the structure of the chromatin inside of cells. The centromere is a structurally and functionally unique region of each chromosome and provides an example in which the molecular understanding far exceeds the understanding of the structure and function relationships that emerge on the chromosomal scale. The centromere is located at the primary constriction of the chromosome. During entry into mitosis, the centromere specifies the assembly site of the kinetochore, the structure that binds to microtubules to enable transport of the chromosomes into daughter cells. The epigenetic contributions to the molecular organization and function of the centromere are reviewed in the context of structural mechanisms of chromatin function.