Early life adversity is associated with a smaller hippocampus in male but not female depressed in-patients: a case-control study.
Early life adversity is associated with a smaller hippocampus in male but not female depressed in-patients: a case-control study.
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DOI：
10.1186/s12888-017-1233-2
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发表时间：
2017-02-15
期刊：
影响因子：
4.4
通讯作者：
Corruble E
中科院分区：
文献类型：
--
作者：
Colle R;Segawa T;Chupin M;Tran Dong MN;Hardy P;Falissard B;Colliot O;Ducreux D;Corruble E
三项研究评估了抑郁症患者早期生活逆境（ELA）和海马体积的相关性，其中一项是阴性的，另外两项没有控制几个潜在的混杂变量。由于ELA和海马体积的关联在男性和女性健康志愿者中不同，我们调查了抑郁症患者ELA和海马体积的关联，同时特别关注性别并控制几个相关的社会人口统计学和临床变量。纳入了63例在精神病环境中接受治疗的抑郁症住院患者，这些患者目前患有重度抑郁发作（MDE）和重度抑郁症（MDD），并对ELA进行了评估。采用脑磁共振成像（MRI）和自动分割技术测量海马体积。对28例ELA患者和35例ELA患者进行比较。双变量分析后，多变量回归分析测试的相互作用，性别和ELA海马体积，并调整了几个潜在的混杂变量。分别评估了男性（n = 26）和女性（n = 37）亚组。ELA患者的海马小于无ELA患者（4.65（±1.11）cm 3 vs 5.25（±1.01）cm 3），双变量：p = 0.03，多变量：HR = 0.40，95%CI [0.23;0.71]，p = 0.002），与其他因素无关。在男性中发现了这种相关性（4.43（±1.22）vs 5.67（±0.77）cm 3），双变量：p = 0.006，多变量HR = 0.23，95%CI [0.06;0.82]，p = 0.03），但在女性中未发现。ELA与男性而非女性抑郁症住院患者的海马较小相关。这种关联的原因应在进一步的研究中进行调查。
Three studies assessed the association of early life adversity (ELA) and hippocampal volumes in depressed patients, of which one was negative and the two others did not control for several potential confounding variables. Since the association of ELA and hippocampal volumes differ in male and female healthy volunteers, we investigated the association of ELA and hippocampal volumes in depressed patients, while focusing specifically on sex and controlling for several relevant socio-demographic and clinical variables. Sixty-three depressed in-patients treated in a psychiatric setting, with a current Major Depressive Episode (MDE) and a Major Depressive Disorder (MDD) were included and assessed for ELA. Hippocampal volumes were measured with brain magnetic resonance imaging (MRI) and automatic segmentation. They were compared between patients with (n = 28) or without (n = 35) ELA. After bivariate analyses, multivariate regression analyses tested the interaction of sex and ELA on hippocampal volume and were adjusted for several potential confounding variables. The subgroups of men (n = 26) and women (n = 37) were assessed separately. Patients with ELA had a smaller hippocampus than those without ELA (4.65 (±1.11) cm3 versus 5.25 (±1.01) cm3), bivariate: p = 0.03, multivariate: HR = 0.40, 95%CI [0.23;0.71], p = 0.002), independently from other factors. This association was found in men (4.43 (±1.22) versus 5.67 (±0.77) cm3), bivariate: p = 0.006, multivariate HR = 0.23, 95%CI [0.06;0.82], p = 0.03) but not in women. ELA is associated with a smaller hippocampus in male but not female depressed in-patients. The reasons for this association should be investigated in further studies.