Nephrolithiasis and risk of hypertension
Nephrolithiasis and risk of hypertension
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DOI：
10.1016/s0895-7061(97)00371-3
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发表时间：
1998-01-01
影响因子：
3.2
通讯作者：
Curhan, GC
中科院分区：
文献类型：
--
作者：
Madore, F;Stampfer, MJ;Curhan, GC
先前的研究表明肾结石与血压之间存在正相关，然而，由于一些先前研究中的方法学问题和缺乏前瞻性数据，仍然存在争议。我们对51,529名男性进行了为期8年的前瞻性跟踪调查，评估了肾结石与高血压风险的关系。信息是通过两年一次的邮寄问卷获得的。ART基线1986年，4111名(8.0%)受试者报告有肾结石病史，11623名(22.6%)受试者被诊断为高血压。年龄调整后的优势比[OR]：1.31；95%可信区间[CI]：1.30-1.32。在报告这两种疾病的男性中，79.5%的人报告说肾结石的发生先于高血压的诊断或伴随高血压的诊断。在基线水平没有高血压的男性中，有肾结石病史的男性与无肾结石病史的男性相比，发生高血压的优势比为1.29(95%可信区间：1.12比1.41；调整了年龄、体重指数和钙、钠、钾、镁和酒精的摄入量)。在随访期间，基线有高血压的男性与无高血压的男性相比，肾结石的发生率相似(调整后的OR：0.99，95%CI：0.82至1.21)。这些数据支持这样的假设，即既往发生肾结石会增加后续高血压的风险。(C)1998年《美国高血压杂志》。
A positive association between nephrolithiasis and blood pressure has been suggested in previous studies, However, controversy remains, due to methodological problems in some of the previous studies and absence of prospective data. We evaluated the relationship between nephrolithiasis and the risk of hypertension in a cohort of 51,529 men followed prospectively for 8 years. information was obtained by biennial mailed questionnaires. Art baseline in 1986, 4111 (8.0%) subjects reported a history of nephrolithiasis and 11,623 (22.6%) a diagnosis of hypertension. A positive association was found between the two disorders (age adjusted odds ratio [OR]: 1.31; 95% confidence interval [CI]: 1.30 to 1.32). Among men who reported both disorders, 79.5% reported that the occurrence of nephrolithiasis was prior to or concomitant with the diagnosis of hypertension. Among men without hypertension at baseline, the odds ratio for incident hypertension in men with a history of nephrolithiasis compared with those without was 1.29 (95% CI: 1.12 to 1.41; adjusted for age, body mass index, and intake of calcium, sodium, potassium, magnesium, and alcohol). The occurrence of incident nephrolithiasis during follow-up was similar in men with hypertension at baseline compared with that in men without (adjusted OR: 0.99, 95% CI: 0.82 to 1.21). These data support the hypothesis that prior occurrence of nephrolithiasis increases the risk of subsequent hypertension. (C) 1998 American Journal of Hypertension, Ltd.