On the Design of a PID Bio-Controller With Set Point Weighting and Filtered Derivative Action
On the Design of a PID Bio-Controller With Set Point Weighting and Filtered Derivative Action
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DOI：
10.1109/lcsys.2022.3182911
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发表时间：
2022-01-01
影响因子：
3
通讯作者：
Papachristodoulou, Antonis
中科院分区：
文献类型：
--
作者：
Alexis, Emmanouil;Cardelli, Luca;Papachristodoulou, Antonis
在不确定和不断变化的生物环境中设计可靠的合成生物器件，对生物分子过程进行有效和稳健的调控至关重要。比例-积分-导数（PID）控制器无疑是现代技术应用中最常用的实现反馈控制的方法。在这里，我们引入了一个高度可调的PID生物控制器，具有设定点加权和过滤导数作用，呈现为具有质量作用动力学的化学反应网络。为了证明其有效性，我们将PID方案应用于两个相互激活的物种的简单生物过程，其中一个被假设为感兴趣的输出。为了突出其性能优势，我们将其与PI调节进行比较，在确定性和随机设置中使用数值模拟。
Effective and robust regulation of biomolecular processes is crucial for designing reliable synthetic bio-devices functioning in uncertain and constantly changing biological environments. Proportional-Integral-Derivative (PID) controllers are undeniably the most common way of implementing feedback control in modern technological applications. Here, we introduce a highly tunable PID bio-controller with set point weighting and filtered derivative action presented as a chemical reaction network with mass action kinetics. To demonstrate its effectiveness, we apply our PID scheme on a simple biological process of two mutually activated species, one of which is assumed to be the output of interest. To highlight its performance advantages we compare it to PI regulation using numerical simulations in both the deterministic and stochastic setting.