Structural and functional associations of the rostral anterior cingulate cortex with subjective happiness
Structural and functional associations of the rostral anterior cingulate cortex with subjective happiness
复制标题
DOI：
10.1016/j.neuroimage.2016.04.020
复制
发表时间：
2016-07-01
期刊：
影响因子：
5.7
通讯作者：
Sadato, Norihiro
中科院分区：
文献类型：
--
作者：
Matsunaga, Masahiro;Kawamichi, Hiroaki;Sadato, Norihiro
幸福是人类最基本的目标之一，这促使研究人员研究个人幸福的来源。幸福通常被讨论为两个相互关联的方面（暂时的积极情绪和特质般的长期幸福感）;例如，具有高水平特质般主观幸福感的个体倾向于将事件评为更愉快。在这项研究中，我们假设幸福的两个方面之间的相互作用可以通过某些大脑区域的结构和功能之间的相互作用来解释。因此，我们首先使用基于体素的形态测量法（VBM）评估了健康参与者的灰质密度（GMD）与特质样主观幸福感之间的关联。此外，为了评估GMD和大脑功能之间的关联，我们使用积极情绪诱导（想象几个情绪生活事件）的任务进行了功能性磁共振成像（MRI）。VBM显示主观幸福感与前扣带皮层（rACC）的GMD呈正相关。功能性磁共振成像显示，实验诱导的暂时性幸福感与主观幸福水平和rACC活性呈正相关。rACC对阳性事件的反应也与其GMD呈正相关。这些结果提供了一致的结构和功能证据表明，rACC与幸福有关，并建议rACC的结构和功能之间的相互作用可以解释幸福的特质-状态相互作用。(C)2016 Elsevier Inc. All rights reserved.
Happiness is one of the most fundamental human goals, which has led researchers to examine the source of individual happiness. Happiness has usually been discussed regarding two aspects (a temporary positive emotion and a trait-like long-term sense of being happy) that are interrelated; for example, individuals with a high level of trait-like subjective happiness tend to rate events as more pleasant. In this study, we hypothesized that the interaction between the two aspects of happiness could be explained by the interaction between structure and function in certain brain regions. Thus, we first assessed the association between gray matter density (GMD) of healthy participants and trait-like subjective happiness using voxel-based morphometry (VBM). Further, to assess the association between the GMD and brain function, we conducted functional magnetic resonance imaging (MRI) using the task of positive emotion induction (imagination of several emotional life events). VBM indicated that the subjective happiness was positively correlated with the GMD of the rostral anterior cingulate cortex (rACC). Functional MRI demonstrated that experimentally induced temporal happy feelings were positively correlated with subjective happiness level and rACC activity. The rACC response to positive events was also positively correlated with its GMD. These results provide convergent structural and functional evidence that the rACC is related to happiness and suggest that the interaction between structure and function in the rACC may explain the trait-state interaction in happiness. (C) 2016 Elsevier Inc. All rights reserved.