Macrovascular and microvascular responses to prolonged sitting with and without bodyweight exercise interruptions: A randomized cross-over trial
Macrovascular and microvascular responses to prolonged sitting with and without bodyweight exercise interruptions: A randomized cross-over trial
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DOI：
10.1177/1358863x211053381
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发表时间：
2021-11-23
影响因子：
3.5
通讯作者：
Stoner, Lee
中科院分区：
文献类型：
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作者：
Horiuchi, Masahiro;Stoner, Lee
持续久坐会导致大血管和微血管并发症，这可能会增加心血管疾病的风险。本研究研究了坐位3h的大血管和微血管反应，即：(I)不间断(CON)；(Ii)每隔20分钟中断一次，光照强度为1min的半蹲加抬高小腿(EX)。20名健康受试者(21[SD：2]岁；21.5[SD：1.6]kg/m(2))被招募参加这项随机交叉试验。大血管功能采用臂踝脉搏波速度(BaPWV)和上下肢动脉僵硬指数(ASI)进行量化。用反应性充血时腓肠肌内侧组织氧饱和度(sto(2))曲线下面积(AUC)来量化微血管功能。BaPWV随时间(p=0.594)和条件(p=0.772)的变化不显著。ARM ASI增加3.6%(95%CI：0.7to6.6，效应大小[ES]=0.27)，没有显著的条件效应(p=0.219)。腿ASI有显著的交互作用(p=0.001)，CON组ASI增加18.7(95%CI：12.1~25.3，ES=0.63)，EX组减少(改善)-11.9(95%CI：-18.5~-5.3，ES=0.4)。同样，CON的AUC降低(有害)18%(Delta=-321，95%CI：-543至-100，ES=0.32)，而EX增加32%(Delta=588，95%CI：366至809，ES=0.59)。小腿ASI与sto(2)AUC呈负相关(组间相关系数：-0.66，95%CI：-0.51~-0.77)。这些初步发现表明，经常中断长时间的静坐，进行简单的体重锻炼，可能有助于保护腿部血管功能。
Exposure to uninterrupted prolonged sitting leads to macro- and microvascular complications, which can contribute to increased cardiovascular disease risk. This study investigated the macrovascular and microvascular responses to 3 h of sitting that was: (i) uninterrupted (CON); and (ii) interrupted every 20 min with 1 min light intensity half squats plus calf raises (EX). Twenty healthy participants (21 [SD: 2] years; 21.5 [SD: 1.6] kg/m(2)) were recruited to participate in this randomized cross-over trial. Macrovascular function was quantified using brachial-ankle pulse wave velocity (baPWV) and the lower- and upper-limb arterial stiffness index (ASI). Microvascular function was quantified as the medial gastrocnemius tissue oxygen saturation (StO(2)) area under the curve (AUC) during reactive hyperemia. The baPWV did not significantly change with time (p = 0.594) or by condition (p = 0.772). The arm ASI increased by 3.6 (95% CI: 0.7 to 6.6, effect size [ES] = 0.27) with a nonsignificant condition effect (p = 0.219). There was a significant interaction effect for leg ASI (p = < 0.001), with ASI increasing (impairment) by 18.7 (95% CI: 12.1 to 25.3, ES = 0.63) for CON and decreasing (improvement) by -11.9 (95% CI: -18.5 to -5.3, ES = 0.40) for EX compared to presitting. Similarly, the AUC decreased (detrimental) by 18% (Delta = -321, 95% CI: -543 to -100, ES = 0.32) for CON and increased by 32% (Delta = 588, 95% CI: 366 to 809, ES = 0.59) for EX. The leg ASI was inversely associated with StO(2) AUC (interclass correlation coefficient: -0.66, 95% CI: -0.51 to -0.77). These preliminary findings suggest that regularly interrupting prolonged sitting with simple bodyweight exercises may help to preserve lower-limb vascular function.