Neural Mechanisms of Reward Prediction Error in Autism Spectrum Disorder.
Neural Mechanisms of Reward Prediction Error in Autism Spectrum Disorder.
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DOI：
10.1155/2019/5469191
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发表时间：
2019-01-01
影响因子：
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通讯作者：
Dichter, Gabriel S
中科院分区：
文献类型：
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作者：
Mosner, Maya G;McLaurin, R Edward;Dichter, Gabriel S
很少有研究探索ASD中奖励学习的神经机制，尽管有证据表明ASD中预测能力的行为障碍。为了研究ASD中奖励预测错误的神经相关性，16名ASD成年人和14名正常发育的对照组在fMRI扫描期间执行了预测错误任务。结果显示，ASD组在有符号的预测错误期间，左扣带回旁回以及在阈值无符号的预测错误期间，左额叶和右额极的激活更大。研究结果支持非典型神经处理的奖励预测错误ASD额纹状体区域的预测编码和奖励学习的关键。结果为奖励学习中的损伤提供了神经基础，这些损伤可能导致ASD中常见的特征（例如，不可预测性（unpredictable）。
Few studies have explored neural mechanisms of reward learning in ASD despite evidence of behavioral impairments of predictive abilities in ASD. To investigate the neural correlates of reward prediction errors in ASD, 16 adults with ASD and 14 typically developing controls performed a prediction error task during fMRI scanning. Results revealed greater activation in the ASD group in the left paracingulate gyrus during signed prediction errors and the left insula and right frontal pole during thresholded unsigned prediction errors. Findings support atypical neural processing of reward prediction errors in ASD in frontostriatal regions critical for prediction coding and reward learning. Results provide a neural basis for impairments in reward learning that may contribute to traits common in ASD (e.g., intolerance of unpredictability).