Matrix Gla protein is associated with risk factors for atherosclerosis but not with coronary artery calcification
Matrix Gla protein is associated with risk factors for atherosclerosis but not with coronary artery calcification
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DOI：
10.1161/01.atv.0000245793.83158.06
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发表时间：
2006-12-01
影响因子：
8.7
通讯作者：
Booth, Sarah L.
中科院分区：
文献类型：
--
作者：
O'Donnell, Christopher J.;Shea, M. Kyla;Booth, Sarah L.
目的：动脉粥样硬化性冠状动脉钙化（CAC）与冠心病（CHD）风险增加有关.基质Gla蛋白（MGP）是体内钙化的抑制剂。然而，鲜为人知的是，关于循环MGP的分布及其与CHD危险因素或CAC在human.Methods和结果-血清MGP浓度测定在2个独立的人群中的男性和女性的临床上明显的心血管疾病：研究A，n = 316，平均年龄58岁，和研究B，n = 452，平均年龄68岁。通过计算机断层扫描确定CAC。在研究A和研究B中，男性的平均MGP浓度分别为98.4和198 ng/mL，女性为97.4和201 ng/mL。在这两个队列中，MGP水平随着年龄的增长而升高。在年龄校正分析中，循环MGP与FRA CHD风险评分增加相关（在研究A中，男性P = 0.003，女性P = 0.016;在研究B中，男性无显著增加，女性P = 0.05）。在两个队列中，循环MGP与高密度脂蛋白和其他个体CHD危险因素也有显著相关性。有没有一致的关联MGP和CAC调整后的CHD风险score in the 2 cohols.Conclusions - MGP与个别CHD危险因素和Frachial CHD风险评分在男性和女性的临床上明显的CHD。MGP与CAC的关系值得在更大的人群中进一步研究。
Objectives - Atherosclerotic coronary artery calcification (CAC) is associated with increased coronary heart disease (CHD) risk. Matrix Gla protein (MGP) is an inhibitor of calcification in vivo. However, little is known regarding the distribution of circulating MGP and its associations with CHD risk factors or with CAC in humans.Methods and Results - Serum MGP concentrations were determined in 2 independent populations of men and women free of clinically apparent cardiovascular disease: study A, n = 316, mean age 58 years, and study B, n = 452, mean age 68 years. CAC was determined by computed tomography. Mean MGP concentrations were 98.4 and 198 ng/mL in men, and 97.4 and 201 ng/mL in women, in study A and study B, respectively. In both cohorts, MGP levels were higher with increasing age. In age-adjusted analyses, there was an association of circulating MGP with increasing Framingham CHD risk score (in study A, P = 0.003 in men and P = 0.016 in women, respectively; in study B, a nonsignificant increase in men and P = 0.05 in women, respectively). Significant associations of circulating MGP with high-density lipoprotein and other individual CHD risk factors were also noted in both cohorts. There were no consistent associations between MGP and CAC after adjustment for CHD risk score in the 2 cohorts.Conclusions - MGP is associated with individual CHD risk factors and the Framingham CHD risk score in men and women free of clinically apparent CHD. The relation of MGP with CAC deserves further study in larger populations.