Are natural killer cells superior CAR drivers?

Are natural killer cells superior CAR drivers?
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DOI:
10.4161/onci.28147
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发表时间:
2014
期刊:
影响因子:
7.2
通讯作者:
Klingemann H
Klingemann H
中科院分区:
医学2区
文献类型:
--
作者:
Klingemann H

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T淋巴细胞工程表达嵌合抗原受体(CAR)被誉为抗癌免疫治疗的重大突破。自然杀伤细胞尚未受到与CAR效应物类似的关注,尽管使用这些相对短寿命的细胞毒性细胞具有几个优点。
T lymphocytes engineered to express a chimeric antigen receptor (CAR) are being celebrated as a major breakthrough of anticancer immunotherapy. Natural killer cells have not received similar attention as CAR effectors, although the use of these relatively short-lived cytotoxic cells is associated with several advantages.
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带有嵌合抗原受体的T细胞具有有效的抗肿瘤作用,可以在晚期白血病患者中建立记忆。
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