Comparing cortical activations for silent and overt speech using event-related fMRI
Comparing cortical activations for silent and overt speech using event-related fMRI
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DOI：
10.1002/hbm.1060
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发表时间：
2002-01-01
影响因子：
4.8
通讯作者：
Cao, Y
中科院分区：
文献类型：
--
作者：
Huang, J;Carr, TH;Cao, Y
目前，功能磁共振成像（fMRI）的皮层语言功能有利于“沉默”的任务范式，没有公开的发言，由于严重的运动伪影的MR图像诱发的发声。在某种程度上，无声说话的神经基础可能不同于公开说话的神经基础，这是理解口语的一个问题。本研究结合事件相关的功能磁共振成像方法与一套技术的运动减少，检测和校正，以进一步调查显性语音，并比较它沉默的讲话。这项研究的目的有两个。我们的目的是测试一个多步骤的图像处理协议，涉及歧视和分离的运动诱导的信号从激活诱导的信号，我们的目的是使用这个多步骤的图像处理协议，比较激活的相似性可能相关的皮层通路的语言生产在无声和公开的讲话，专注于布罗卡区的初级运动皮层作为测试用例。如果运动伪影的问题能得到有效的处理，功能磁共振成像可以大大增加可用的工具来研究人类语言。(C)2001 Wiley-Liss，Inc.
At present, functional magnetic resonance imaging (fMRI) of cortical language functions favors "silent" task paradigms with no overt speaking, due to severe motion artifacts in MR images induced by vocalization. To the extent that the neural substrate of silent speaking might differ from that of overt speaking, this is a problem for understanding spoken language. The present study combined event related fMRI methodology with a set of techniques for motion reduction, detection, and correction to further investigate overt speech and compare it to silent speech. The purpose of the study was two-fold. We aimed to test a multiple-step image processing protocol involving discrimination and separation of motion-induced signals from activation-induced signals and we aimed to use this multi-step image processing protocol to compare the similarity of activation of cortical pathways potentially relevant to language production during silent and overt speech, focusing on Broca area an primary motor cortex as test cases. If the problem of motion artifact can be handled effectively, fMRI can add greatly to the tools available to investigate human language. (C) 2001 Wiley-Liss, Inc.