Studies on the involvement of melatonergic mechanism in intraocular pressure regulation.
Studies on the involvement of melatonergic mechanism in intraocular pressure regulation.
复制标题
褪黑激素机制参与眼压调节的研究。
作者：
G. Chiou;M. Mclaughlin
据报道，眼内压（IOP）的昼夜变化可能与眼内褪黑激素水平的波动有关。为了验证这一假设，我们研究了甲塞吉特、丙氨酰环丙胺和对氯苯丙氨酸（PCPA）对高渗生理盐水家兔IOP恢复的影响。Methysergide是一种受体部位的5 -羟色胺阻滞剂，它不影响IOP的恢复，可能是因为它不影响褪黑激素的合成。tranyylcypromine是一种单胺氧化酶抑制剂，可以保留血清素，并最终增加组织中褪黑激素的水平，促进IOP的恢复。PCPA，已知抑制血清素合成和降低组织中褪黑素水平，明显延迟IOP的恢复。这些结果表明，一种化学物质会降低眼睛中褪黑激素的含量，也会降低IOP，反之亦然。提示IOP的昼夜节律可能与褪黑激素机制有关。
It has been reported that diurnal changes in intraocular pressure (IOP) may be related to the fluctuation of melatonin levels in the eye. In order to test this hypothesis, effects of methysergide, tranylcypromine, and p-chlorophenylalanine (PCPA) on IOP recovery were studied in rabbits infused with hypertonic saline. Methysergide, a serotonin blocker at receptor sites, did not affect IOP recovery, presumably because it did not affect melatonin synthesis. Tranylcypromine, a monoamine oxidase inhibitor which preserves serotonin and eventually increases the level of melatonin in tissues, facilitated IOP recovery. PCPA, known to inhibit serotonin synthesis and to lower the melatonin level in tissues, markedly delayed IOP recovery. These results indicate that a chemical which decreases melatonin content in the eye also lowers the IOP and vice versa. It is suggested that some melatonergic mechanism is involved in the circadian rhythm of IOP.