Liquid biopsy: a new diagnostic, predictive and prognostic window in cancers of unknown primary
Liquid biopsy: a new diagnostic, predictive and prognostic window in cancers of unknown primary
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DOI：
10.1016/j.ejca.2018.09.035
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发表时间：
2018-12-01
影响因子：
8.4
通讯作者：
Pavlidis, Nicholas
中科院分区：
文献类型：
--
作者：
El Rassy, Elie;Khaled, Hussein;Pavlidis, Nicholas
原发灶不明的癌症（CUP）是一组异质性转移性癌症，其特征是在没有任何可识别的原发部位的情况下发生早期转移。传统的诊断和治疗方法大多数CUP患者预后差。认识到假定的原发性肿瘤被假设为通过指导治疗决策来改善CUP患者的预后。在分子肿瘤学中的积极努力已经表明，基因表达谱能够识别原发性肿瘤部位并确定可靶向的突变。在这方面，液体活检为CUP开辟了一个新的诊断、预测和预后窗口，可能会大大改善CUP患者的管理。(C)2018爱思唯尔有限公司版权所有
Cancer of unknown primary (CUP) is a heterogeneous group of metastatic cancers characterised by early dissemination of metastases in the absence of any identifiable primary site. Most patients with CUP have poor prognosis with the traditional diagnostic and treatment modalities. Recognising the putative primary tumour is hypothesised to ameliorate the prognosis of patients with CUP by guiding treatment decisions. The active efforts in molecular oncology have shown that gene expression profiling is able to identify the primary tumour site and to determine targetable mutations. In this regard, liquid biopsy opens a new diagnostic, predictive and prognostic window in CUP that may lead to substantial improvement in the management of patients with CUP. (C) 2018 Elsevier Ltd. All rights reserved.