High performance dental resin composites with hydrolytically stable monomers
High performance dental resin composites with hydrolytically stable monomers
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DOI：
10.1016/j.dental.2017.10.007
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发表时间：
2018-02-01
期刊：
影响因子：
5
通讯作者：
Sun, Jirun
中科院分区：
文献类型：
--
作者：
Wang, Xiaohong;Huyang, George;Sun, Jirun
目标。本项目的目标是：1)通过使用具有水解性稳定性的新型单体来开发坚固耐用的牙科树脂复合材料；2)在与临床应用相关的测试条件下，证明基于这些单体的树脂复合材料的性能优于传统的双酚A甲基丙烯酸缩水甘油酯/三甘醇二甲基丙烯酸酯(Bis-GMA/TEGDMA)复合材料。通过控制组成的光聚合方法，合成了三甘醇二乙烯基苄基醚(TEG-DVBE)和氨基甲酸二甲基丙烯酸酯(UDMA)等新型树脂。其复合材料中含有67.5wt%的微米和7.5wt%的纳米填料。通过一系列临床相关的评估来评估共聚物和复合材料的性能：乙烯基转化率(DC：FTIR和NIR光谱)；折射率(n：光学显微镜)；弹性模量(E)、弯曲强度(F)和断裂韧性(K-IC)(通用机械测试)；努氏硬度(HK；压痕)；吸水率(W-SP)和溶解度(W-Su)(重量法)；聚合收缩(S压力计)和聚合应力(张力计)。将实验制备的UDMA/TEG-DVBE复合材料与相同填充量的双GMA/TEGDMA复合材料以及商用微细混杂流动复合材料进行了比较。UDMA/TEG-DBVE复合材料的n、E、W-sp、W-su和S-upsilon与对照组相当。它们在F(高达26.8%)、K-IC(高达27.7%)、吸水模数恢复(完全恢复比91.9%)和应力形成(高达52.7%)方面优于对照组。此外，与传统复合材料相比，新型复合材料的可获得DC增加了27.7%。BIS-GMA/TEGDMA控制组仅在一项性能上超过了实验复合材料，即复合材料的硬度。值得注意的是，在实验系列中，高达18.1%的低Hk值(0.458 GPa值)仍高于临床要求的阈值约。0.4GPA，意义重大。新型树脂复合材料的水解稳定性、成分控制聚合和临床相关性能的全面提高使其成为取代传统树脂复合材料作为新一代强大和耐用的牙科修复剂的候选材料。(C)2017年牙科材料学院。爱思唯尔有限公司出版。保留所有权利。
Objective. The objectives of this project were to: 1) develop strong and durable dental resin composites by employing new monomers that are hydrolytically stable, and 2) demonstrate that resin composites based on these monomers perform superiorly to the traditional bisphenol A glycidyl dimethacrylate/triethylene glycol dimethacrylate (Bis-GMA/TEGDMA) composites under testing conditions relevant to clinical applications.Methods. New resins comprising hydrolytically stable, ether-based monomer, i.e., triethylene glycol divinylbenzyl ether (TEG-DVBE), and urethane dimethacrylate (UDMA) were produced via composition-controlled photo-polymerization. Their composites contained 67.5 wt% of micro and 7.5 wt% of nano-sized filler. The performances of both copolymers and composites were evaluated by a battery of clinically-relevant assessments: degree of vinyl conversion (DC: FTIR and NIR spectroscopy); refractive index (n: optical microscopy); elastic modulus (E), flexural strength (F) and fracture toughness (K-IC) (universal mechanical testing); Knoop hardness (HK; indentation); water sorption (W-sp) and solubility (W-su) (gravimetry); polymerization shrinkage (S-upsilon; mercury dilatometry) and polymerization stress (tensometer). The experimental UDMA/TEG-DVBE composites were compared with the BisGMA/TEGDMA composites containing the identical filler contents, and with the commercial micro hybrid flowable composite.Results. UDMA/TEG-DBVE composites exhibited n, E, W-sp, W-su and S-upsilon equivalent to the controls. They outperformed the controls with respect to F (up to 26.8% increase), K-IC (up to 27.7% increase), modulus recovery upon water sorption (full recovery vs. 91.9% recovery), and stress formation (up to 52.7% reduction). In addition, new composites showed up to 27.7% increase in attainable DC compared to the traditional composites. Bis-GMA/TEGDMA controls exceeded the experimental composites with respect to only one property, the composite hardness. Significantly, up to 18.1% lower HK values in the experimental series (0.458 GPa) were still above the clinically required threshold of approx. 0.4 GPa.Significance. Hydrolytic stability, composition-controlled polymerization and the overall enhancement in clinically-relevant properties of the new resin composites make them viable candidates to replace traditional resin composites as a new generation of strong and durable dental restoratives. (C) 2017 The Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.