The importance of a luteolytic effect of the pituitary in understanding the placental control of the rat corpus luteum.
The importance of a luteolytic effect of the pituitary in understanding the placental control of the rat corpus luteum.
复制标题
垂体的黄体溶解作用对于了解大鼠黄体的胎盘控制的重要性。
DOI：
10.1210/endo-112-5-1687
复制
发表时间：
1983
期刊：
影响因子：
4.8
通讯作者：
I. Rothchild
中科院分区：
文献类型：
--
作者：
K. Ochiai;H. Kato;P. Kelly;I. Rothchild
在大鼠轴承完整的补充孕体（FC轴承大鼠）孕酮分泌增加约1.5倍，黄体重量增加一倍之间的第12和16天。在妊娠第7天和第12天（第1天=授精）之间的任何时间将孕体数量减少到1个（通过抽吸除单个孕体之外的所有孕体），导致孕酮分泌和黄体重量保持在或低于第12天的水平，直到足月。当大鼠轴承一个孕体在第12天垂体切除术，然而，血清孕酮增加和下降后的模式几乎相同的FC轴承大鼠，除了高峰和低谷发生在约2天后，第12天;垂体切除术在第15或18天也增加血清孕酮接近完整的FC轴承大鼠的值。在一系列实验确定的孕体数为0 - 5或自然产生的孕体数为6-16的大鼠中，第12天（该激素分泌的第一个高峰日）胎盘催乳素的血清水平与整个范围内的孕体数成正比。大鼠胎盘催乳素分泌的模式之间的第7天和第23天的FC轴承大鼠包括两个高峰，在第12天和第18-21天，但在一个孕轴承大鼠，水平仅略高于PRL水平，并保持不变，甚至垂体切除术，直到任期。血清PRL水平没有关系的孕数，是非常低的，并没有受到垂体切除术的影响，除了在FC轴承大鼠，其中lypophysectomy防止上升，通常发生在第21天后。这些结果，特别是与以前报道的其他结果有关，表明到妊娠第12天，大鼠垂体不仅没有促黄体活性，反而产生了一种抑制黄体进一步发育的物质。结果还表明，胎盘维持黄体生长和孕酮分泌的抑制这种黄体溶解活性，直接刺激黄体。
In rats bearing a full complement of conceptuses (FC-bearing rats) progesterone secretion increases about 1.5 times and the corpora lutea double in weight between days 12 and 16. Reducing the number of conceptuses to one (by aspirating all but the single conceptus) at any time between days 7 and 12 of pregnancy (day 1 = insemination) caused progesterone secretion and corpus luteum weight to remain at or below the day 12 level until term. When rats bearing one conceptus were hypophysectomized on day 12, however, serum progesterone increased and fell after day 12 in a pattern almost identical to that in FC-bearing rats, except that the peak and trough occurred about 2 days later; hypophysectomy on day 15 or 18 also increased serum progesterone to values approaching those in intact FC-bearing rats. In a series of rats bearing experimentally determined conceptus numbers between 0 and 5 or naturally occurring ones of 6-16, the serum level of placental lactogen on day 12 (the day of the first peak of secretion of this hormone) was directly proportional to conceptus number over the entire range. The pattern of rat placental lactogen secretion between days 7 and 23 in FC-bearing rats included two peaks, on day 12 and on days 18-21, but in one-conceptus-bearing rats, the level was only slightly higher than the PRL level, and it remained unchanged, even by hypophysectomy, until term. Serum PRL levels bore no relation to conceptus number, were very low, and were unaffected by hypophysectomy except in the FC-bearing rats, in which lypophysectomy prevented the rise that normally occurs after day 21. These results, especially in relation to others previously reported, show that by day 12 of pregnancy, the rat pituitary, instead of merely becoming luteotropically inactive, produces a substance that inhibits further development of the corpora lutea. The results also imply that the placentas maintain luteal growth and progesterone secretion as much by suppressing this luteolytic activity as by stimulating the corpus luteum directly.
有证据表明，来自母体垂体的黄体生成素可能促进大鼠产前松弛素的释放、黄体溶解和分娩。
影响因子：
4.8
作者：
Gordon,WL;Sherwood,OD
通讯作者：
Sherwood,OD