The relative contributions of scatter and attenuation corrections toward improved brain SPECT quantification.
The relative contributions of scatter and attenuation corrections toward improved brain SPECT quantification.
复制标题
散射和衰减校正对改善大脑 SPECT 量化的相对贡献。
DOI：
--
复制
发表时间：
1998
影响因子：
3.5
通讯作者：
R. Nicholson
中科院分区：
文献类型：
--
作者：
R. Stodilka;B. Kemp;P. Msaki;F. Prato;R. Nicholson
越来越多的证据表明，散射和衰减是定量 SPECT 客观诊断脑部疾病的主要障碍。然而，关于散射校正 (SC) 和衰减校正 (AC) 的相对重要性以及如何实施它们，存在相当多的争论。使用两室完全组织等效的拟人头部模型评估 SC 和 AC 对 99mTc 脑部 SPECT 的功效。实施了四种校正方案：均匀宽束AC、非均匀宽束AC、均匀SC+AC和非均匀SC+AC。 SC 基于非平稳反卷积散射减法，经过修改以纳入头部轮廓（均匀 SC）或传输图（非均匀 SC）的先验知识。校正方案的定量准确性根据对比度恢复、相对定量（皮质：小脑活动）、均匀性（（230 个宏观体素的变异系数）x 100%）和偏差（相对于校准扫描）进行评估。我们的结果是：均匀宽光束 (mu = 0.12 cm(-1)) AC（最流行的校正）：71% 对比度恢复、112% 相对量化、7.0% 均匀性、+23% 偏差。非均匀宽光束（软组织mu = 0.12 cm(-1)）AC：分别为73%、114%、6.0%、+21%。均匀 SC + AC：分别为 90%、99%、4.9%、+12%。非均匀 SC + AC：分别为 93%、101%、4.0%、+10%。 SC和AC达到最佳量化效果；然而，与均匀校正相比，非均匀校正仅产生很小的改进。发现SC+AC优于AC；这一优势在所有四个量化指标中都是明显且一致的。
Mounting evidence indicates that scatter and attenuation are major confounds to objective diagnosis of brain disease by quantitative SPECT. There is considerable debate, however, as to the relative importance of scatter correction (SC) and attenuation correction (AC), and how they should be implemented. The efficacy of SC and AC for 99mTc brain SPECT was evaluated using a two-compartment fully tissue-equivalent anthropomorphic head phantom. Four correction schemes were implemented: uniform broad-beam AC, non-uniform broad-beam AC, uniform SC + AC, and non-uniform SC + AC. SC was based on non-stationary deconvolution scatter subtraction, modified to incorporate a priori knowledge of either the head contour (uniform SC) or transmission map (non-uniform SC). The quantitative accuracy of the correction schemes was evaluated in terms of contrast recovery, relative quantification (cortical:cerebellar activity), uniformity ((coefficient of variation of 230 macro-voxels) x 100%), and bias (relative to a calibration scan). Our results were: uniform broad-beam (mu = 0.12 cm(-1)) AC (the most popular correction): 71% contrast recovery, 112% relative quantification, 7.0% uniformity, +23% bias. Non-uniform broad-beam (soft tissue mu = 0.12 cm(-1)) AC: 73%, 114%, 6.0%, +21%, respectively. Uniform SC + AC: 90%, 99%, 4.9%, +12%, respectively. Non-uniform SC + AC: 93%, 101%, 4.0%, +10%, respectively. SC and AC achieved the best quantification; however, non-uniform corrections produce only small improvements over their uniform counterparts. SC + AC was found to be superior to AC; this advantage is distinct and consistent across all four quantification indices.
登录
查看更多内容
使用伽马相机确定的充满水的模型中的 Tc-99m 衰减系数。
影响因子：
3.8
作者：
Harris,CC;Greer,KL;Jaszczak,RJ;FloydJr,CE;Fearnow,EC;Coleman,RE
通讯作者：
Coleman,RE
使用蒙特卡罗模拟源分布的四种散射校正方法的比较。
DOI：
--
发表时间：
1994
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Ljungberg,M;King,MA;Hademenos,GJ;Strand,SE
通讯作者：
Strand,SE
通过重复 Technetium-99m-HMPAO SPECT 测量脑血流的区域稳定性：对状态依赖性变化研究的影响。
DOI：
--
发表时间：
1997
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
影响因子：
--
作者：
Deutsch,G;Mountz,JM;Katholi,CR;Liu,HG;Harrell,LE
通讯作者：
Harrell,LE
使用 iodine-123-IBZM 对人体多巴胺 D2 受体进行动态 SPECT 成像。
DOI：
--
发表时间：
1992
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Seibyl,JP;Woods,SW;Zoghbi,SS;Baldwin,RM;Dey,HM;Goddard,AW;Zea-Ponce,Y;Zubal,G;Germine,M;Smith,EO
通讯作者：
Smith,EO
technetium-99m-HMPAO 和 technetium-99m-ECD 大脑 SPECT 图像在阿尔茨海默病中的比较。
DOI：
--
发表时间：
1996
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
vanDyck,CH;Lin,CH;Smith,EO;Wisniewski,G;Cellar,J;Robinson,R;Narayan,M;Bennett,A;Delaney,RC;Bronen,RA;Hoffer,PB
通讯作者：
Hoffer,PB