Perceptual responses in patients with inflammatory and functional bowel disease
Perceptual responses in patients with inflammatory and functional bowel disease
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DOI：
10.1136/gut.47.4.497
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发表时间：
2000-10-01
期刊：
影响因子：
24.5
通讯作者：
Matin, K
中科院分区：
文献类型：
--
作者：
Chang, L;Munakata, J;Matin, K
背景和目的——内脏短暂炎症过程后内脏敏感性增强被认为是肠易激综合征（IBS）的病因机制。在这项研究中，我们比较了轻度慢性直肠炎症（溃疡性结肠炎（UC））患者和无粘膜炎症（IBS）患者对直肠乙状结肠扩张的知觉反应，以确定慢性低度粘膜炎症是否可能是IBS和UC患者报告的直肠乙状结肠过敏的合理解释。方法-使用活动指数评分对UC疾病活动进行量化。比较了 11 名静止或轻度疾病活动的 UC 患者、18 名 IBS 患者和 13 名健康对照者在直肠乙状结肠扩张期间不适的知觉阈值。结果-尽管 UC 活动指数评分与不适知觉阈值负相关（r=-0.76，p=0.016），但与 IBS 患者和对照之前（p=0.02）和之后（p）相比，UC 患者具有更高的不适阈值。
Background and aims-Enhanced visceral sensitivity following a transient inflammatory process in the got has been postulated as an aetiological mechanism of irritable bowel syndrome (IBS). In this study we compared perceptual responses to rectosigmoid distension in patients with mild chronic inflammation of the rectum (ulcerative colitis (UC)) and patients without mucosal inflammation (IBS) to determine if chronic low grade mucosal inflammation may be a plausible explanation for rectosigmoid hypersensitivity reported in both IBS and UC patients.Methods-UC disease activity was quantified using activity index scores. Perception thresholds for discomfort during rectosigmoid distension were compared between 11 UC patients with quiescent or mild disease activity, 18 IBS patients, and 13 healthy controls.Results-Although UC activity index scores negatively correlated with perceptual thresholds for discomfort (r=-0.76, p=0.016), UC patients had higher discomfort thresholds compared with IBS patients and controls before (p=0.02) and after (p