PHENACYL ESTERS OF FATTY-ACIDS VIA CROWN ETHER CATALYSTS FOR ENHANCED ULTRAVIOLET DETECTION IN LIQUID-CHROMATOGRAPHY
PHENACYL ESTERS OF FATTY-ACIDS VIA CROWN ETHER CATALYSTS FOR ENHANCED ULTRAVIOLET DETECTION IN LIQUID-CHROMATOGRAPHY
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DOI：
10.1021/ac60361a025
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发表时间：
1975-01-01
影响因子：
7.4
通讯作者：
GRUSHKA, E
中科院分区：
文献类型：
--
作者：
DURST, HD;MILANO, M;GRUSHKA, E
Phenacyl esters of fatty acids have been formed In an es-sentially quantitative manner using crown ethers as catalysts. These esters absorb UV radiation strongly at 254 nm, allowing the detection of as small a quantity as 1 ng of C2 acid, and 50 ng of C20 acid. The method of synthesis is in-expensive and can be carried out in virtually any aprotic solvent system in a short period of time. Reaction conditions do not require total exclusion of water, thus simplifying the procedure. Liquid chromatographic separations of these es-ters have been obtained on a 25-cm long column packed with Cg bonded phase. The implications and uses of such a broad ranging synthesis are discussed.Several reasons can be given for the use of derivatization in chromatography: eg, toenhance solute volatility (GC), to enhance separation, and to enhance detectability. The selection of a derivative can often become much more diffi-cult than the actual derivatization itself. In all areas of chromatography, the above effects have been successfully applied to difficult or otherwise impossible separations. Some recent examplesof derivatization for volatility en-hancement are the study of Myher et al.(1) and of McMa-hon and Crowell (2). In liquid chromatography, Timko et al.(3) utilized derivatives of amino acids for separation en-hancement.
