BIND: the Biomolecular Interaction Network Database
BIND: the Biomolecular Interaction Network Database
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DOI：
10.1093/nar/gkg056
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发表时间：
2003-01-01
影响因子：
14.9
通讯作者：
Hogue, CWV
中科院分区：
文献类型：
--
作者：
Bader, GD;Betel, D;Hogue, CWV
生物分子相互作用网络数据库(BIND：http://bind.ca))记录了生物分子相互作用、复合体和途径信息。可使用基于网络的系统来查询、查看和提交记录。随着来自PDB的个人提交和相互作用数据的增加，BIND继续增长，以及使用酵母双杂交、质谱学、遗传相互作用和噬菌体展示进行的一些大规模相互作用和复杂的图谱实验。我们开发了一种新的图形分析工具，为用户提供了相互作用和复杂记录中蛋白质的结构域组成的视图，以帮助将功能结构域与蛋白质相互作用联系起来。还开发了一个互动网络集群工具，以帮助重点关注感兴趣的区域。来自用户的持续输入帮助BIND数据规范进一步成熟，该规范现在包括存储关于遗传相互作用的详细信息的能力。绑定数据规范以ASN.1和XMLDTD的形式提供。
The Biomolecular Interaction Network Database (BIND: http://bind.ca) archives biomolecular interaction, complex and pathway information. A web-based system is available to query, view and submit records. BIND continues to grow with the addition of individual submissions as well as interaction data from the PDB and a number of large-scale interaction and complex mapping experiments using yeast two hybrid, mass spectrometry, genetic interactions and phage display. We have developed a new graphical analysis tool that provides users with a view of the domain composition of proteins in interaction and complex records to help relate functional domains to protein interactions. An interaction network clustering tool has also been developed to help focus on regions of interest. Continued input from users has helped further mature the BIND data specification, which now includes the ability to store detailed information about genetic interactions. The BIND data specification is available as ASN.1 and XML DTD.