Triboelectric nanogenerators for sensitive nano-coulomb molecular mass spectrometry
Triboelectric nanogenerators for sensitive nano-coulomb molecular mass spectrometry
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DOI：
10.1038/nnano.2017.17
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发表时间：
2017-05-01
影响因子：
38.3
通讯作者：
Fernandez, Facundo M.
中科院分区：
文献类型：
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作者：
Li, Anyin;Zi, Yunlong;Fernandez, Facundo M.
用于分子质谱的离子源通常由直流电源驱动，用户无法控制产生的总电荷。在这里，我们表明，摩擦电纳米发电机（TENGs）的输出可以定量控制总电离电荷在质谱。TENG的高输出电压可以产生单极性或交替极性的离子脉冲，并且是诱导纳米电喷雾电离（nanoESI）和等离子体放电电离的理想选择。对于给定的nanoESI发射器，以1.0 nC的起始电荷递送范围从1.0至5.5 nC的精确控制的离子脉冲。喷雾脉冲可以以17 Hz的高频（周期为60 ms）产生，脉冲持续时间可按需在60 ms和5.5 s之间调节。高灵敏度（类似于0.6 zeptomole）的质谱分析，使用最小的样品（18 pl/脉冲）实现了10 pg ml（-1）可卡因样品。我们还表明，天然蛋白质构象是保守的TENG-ESI，和图案化的离子沉积在导电和绝缘表面是可能的。
Ion sources for molecular mass spectrometry are usually driven by direct current power supplies with no user control over the total charges generated. Here, we show that the output of triboelectric nanogenerators (TENGs) can quantitatively control the total ionization charges in mass spectrometry. The high output voltage of TENGs can generate single-or alternating-polarity ion pulses, and is ideal for inducing nanoelectrospray ionization (nanoESI) and plasma discharge ionization. For a given nanoESI emitter, accurately controlled ion pulses ranging from 1.0 to 5.5 nC were delivered with an onset charge of 1.0 nC. Spray pulses can be generated at a high frequency of 17 Hz (60 ms in period) and the pulse duration is adjustable on-demand between 60 ms and 5.5 s. Highly sensitive (similar to 0.6 zeptomole) mass spectrometry analysis using minimal sample (18 pl per pulse) was achieved with a 10 pg ml(-1) cocaine sample. We also show that native protein conformation is conserved in TENG-ESI, and that patterned ion deposition on conductive and insulating surfaces is possible.