Social Cognition and Emotional Assessment differentiates frontotemporal dementia from depression
Social Cognition and Emotional Assessment differentiates frontotemporal dementia from depression
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DOI：
10.1136/jnnp-2011-301849
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发表时间：
2012-04-01
影响因子：
11
通讯作者：
Sarazin, Marie
中科院分区：
文献类型：
--
作者：
Bertoux, Maxime;Delavest, Marine;Sarazin, Marie
背景额颞叶痴呆的行为变体（bvFTD）是一种神经退行性疾病，临床特征为进行性行为改变和社会人际功能障碍。它的诊断仍然是一个临床挑战，目的评价社会认知和情绪评估量表（SEA）和简易SEA量表（mini-SEA）在bvFTD与重性抑郁障碍（MDD）鉴别诊断中的敏感性和特异性（根据Mattis痴呆评定量表的正常范围，分为17例早期bvFTD和20例中度bvFTD亚组），将19例MDD患者和30例对照者与其他标准神经心理学测试进行比较，以确定这些工具的区分能力。与对照受试者和MDD组相比，早期和中度bvFTD组的SEA评分均显著较低，bvFTD亚组患者与MDD和对照亚组患者之间的评分很少重叠。结论SEA和mini-SEA评分与标准执行神经心理学测验不同，可在疾病早期鉴别bvFTD和MDD。迷你SEA是一种简单的工具，可用于神经科或精神科。
Background Behavioural variant of frontotemporal dementia (bvFTD) is a neurodegenerative disease that is clinically characterised by progressive behavioural changes and social interpersonal dysfunctions. Its diagnosis remains a clinical challenge, and depression is one of the main causes of misdiagnoses due to the prevalence of apathy in bvFTD.Objective To evaluate the sensitivity and specificity of the Social Cognition and Emotional Assessment (SEA) and the mini-SEA for differentiating bvFTD from major depressive disorder (MDD).Methods Scores for the SEA and mini-SEA for 37 patients with bvFTD (divided into subgroups of 17 with early bvFTD and 20 with moderate bvFTD according to the normal range of the Mattis Dementia Rating Scale), 19 MDD patients and 30 control subjects were compared to define the discrimination power of these tools compared with other standard neuropsychological tests.Results SEA and mini-SEA scores were significantly lower for both the early and moderate bvFTD groups compared with control subjects and the MDD group, and very few scores overlapped between patients in the bvFTD subgroups and patients in the MDD and control subgroups. SEA and mini-SEA scores distinguished early bvFTD from MDD with sensitivity and specificity rates above 94%.Conclusion Unlike standard executive neuropsychological tests, SEA and the mini-SEA can differentiate MDD from bvFTD in the early stages of the disease. The mini-SEA is an easy tool that can be utilised in neurological or psychiatric departments.