Identification of a variable region at the carboxy terminus of SV40 large T-antigen.
Identification of a variable region at the carboxy terminus of SV40 large T-antigen.
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SV40 大 T 抗原羧基末端可变区的鉴定。
DOI：
10.1006/viro.1996.0386
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Butel,JS
中科院分区：
文献类型：
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作者：
Stewart,AR;Lednicky,JA;Benzick,US;Tevethia,MJ;Butel,JS
对猴病毒40（SV 40）的三个人类分离株以及从猴子身上回收的两个实验室毒株的整个早期区域进行了测序。与参比菌株SV 40 -776相比，各分离株的早期编码区均包含许多核苷酸差异。这些差异导致小T抗原的独特区域的预测氨基酸序列和大T抗原的羧基（C）末端的一些变化。其余大T抗原的氨基酸序列在所有分离株中是绝对保守的。因此，SV 40大T抗原在分子的C末端含有可变结构域。
The entire early regions of three human isolates of simian virus 40 (SV40), as well as two laboratory strains recovered from monkeys, were sequenced. The early coding region of each isolate contains a number of nucleotide differences when compared to the reference strain SV40-776. These differences result in some changes in the predicted amino acid sequence of the unique region of small t-antigen and in the carboxy (C) terminus of large T-antigen. The amino acid sequence of the remainder of large T-antigen was absolutely conserved among all isolates. Thus, SV40 large T-antigen contains a variable domain at the C-terminal end of the molecule.