Computed tomography for imaging the breast
Computed tomography for imaging the breast
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DOI：
10.1007/s10911-006-9017-1
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发表时间：
2006-04-01
影响因子：
2.5
通讯作者：
Nelson, Thomas R.
中科院分区：
文献类型：
--
作者：
Boone, John M.;Kwan, Alex L. C.;Nelson, Thomas R.
尽管筛查乳房X光检查的成功有助于降低癌症死亡率，但其他一些成像技术正在研究中，用于乳腺癌筛查。在我们的实验室，一种专用的乳房计算机断层扫描(CT)系统已经开发出来，目前正在接受患者测试。乳房CT系统能够在女性俯卧在桌面上、乳房处于悬垂位置时扫描乳房。一次360度扫描目前需要16.6%的S，第二台扫描时间为9秒的扫描仪几乎可以运行。在CT几何结构下对乳房的辐射剂量进行了广泛的计算，并选择了扫描参数以利用与双视图相同的辐射剂量水平。在第一阶段试验中，共有55名女性接受了扫描，在第一阶段试验中，有10名健康志愿者，在第二阶段试验中，有45名女性患有乳腺癌的可能性很高。乳房CT过程导致为每个乳房产生大约300512x512的图像。对乳腺CT图像的主观评价显示，与脂肪组织相比，乳腺CT图像具有良好的解剖细节、对微钙化的良好描述以及对肿瘤软组织成分的精细可视化。碘造影剂的使用极大地增强了肿瘤的可视化。虽然基于观察者表现研究的全面科学调查正在进行中，但最初的乳房CT图像确实看起来很有希望，很可能乳房CT将在乳腺癌成像中发挥一定的作用。
Despite the success of screening mammography contributing to the reduction of cancer mortality, a number of other imaging techniques are being studied for breast cancer screening. In our laboratory, a dedicated breast computed tomography (CT) system has been developed and is currently undergoing patient testing. The breast CT system is capable of scanning the breast with the woman lying prone on a tabletop, with the breast in the pendant position. A 360 degrees scan currently requires 16.6 s, and a second scanner with a 9-second scan time is nearly operational. Extensive effort was placed on computing the radiation dose to the breast under CT geometry, and the scan parameters are selected to utilize the same radiation dose levels as two-view mammography. A total of 55 women have been scanned, ten healthy volunteers in a Phase I trial, and 45 women with a high likelihood of having breast cancer in a Phase II trial. The breast CT process leads to the production of approximately three hundred 512 x 512 images for each breast. Subjective evaluation of the breast CT images reveals excellent anatomical detail, good depiction of microcalcifications, and exquisite visualization of the soft tissue components of the tumor when contrasted against adipose tissues. The use of iodine contrast injection dramatically enhances the visualization of tumors. While a thorough scientific investigation based upon observer performance studies is in progress, initial breast CT images do appear promising and it is likely that breast CT will play some role in breast cancer imaging.