A meta-analysis of maternal cured meat consumption during pregnancy and the risk of childhood brain tumors
A meta-analysis of maternal cured meat consumption during pregnancy and the risk of childhood brain tumors
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DOI：
10.1159/000073979
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发表时间：
2004-01-01
影响因子：
5.7
通讯作者：
Kupelnick, B
中科院分区：
文献类型：
--
作者：
Huncharek, M;Kupelnick, B
目的：N-亚硝基化合物（NOC）在动物模型中被认为是神经致癌物，并且被怀疑是人类致癌物。一项荟萃分析研究了母亲在怀孕期间摄入腌肉（膳食 NOC 的重要来源）与儿童脑肿瘤风险之间的可能关联。方法：使用基于一般方差的荟萃分析方法（采用 Greenland 1986 年描述的置信区间）汇总流行病学研究的数据。感兴趣的结果是总结相对风险 (RR)，反映与母亲在怀孕期间摄入腌肉相关的儿童脑肿瘤 (CBT) 发展风险。必要时进行敏感性分析以解释任何观察到的统计异质性。结果：发现七项观察性研究符合方案规定的纳入标准。异质性分析表明缺乏统计异质性（p = 0.59），表明数据可以进行统计合并。汇集包含所有类型孕产妇腌肉摄入量数据的 6 份报告的数据得出 RR 为 1.68 (1.30 2.17)，这是一个具有统计显着性的结果。按摄入腌肉类型分析 CBT 风险表明，食用热狗会使 CBT 风险增加 33% (1.08 - 1.66)，频繁摄入香肠也会增加类似的风险，即 44%。结论：这些数据支持了怀孕期间摄入腌肉中的 NOC 与后代 CBT 之间可疑的因果关系。研究设计的局限性无法得出明确的结论，但这种关系值得通过额外的观察和实验室研究来探索。版权所有 (C) 2004 S. Karger AG，巴塞尔。
Objective: N-Nitroso compounds (NOCs) are recognized neural carcinogens in animal models and are suspected human carcinogens. A meta-analysis was performed examining the possible association of maternal intake of cured meat ( an important source of dietary NOCs) during pregnancy and the risk of pediatric brain tumors. Methods: Data from epidemiological studies were pooled using a general variance-based meta-analytic method employing confidence intervals described by Greenland in 1986. The outcome of interest was a summary relative risk (RR) reflecting the risk of childhood brain tumor (CBT) development associated with maternal intake of cured meats during pregnancy. Sensitivity analyses were performed when necessary to explain any observed statistical heterogeneity. Results: Seven observational studies were found that met the protocol-specified inclusion criteria. Analysis for heterogeneity demonstrated a lack of statistical heterogeneity ( p = 0.59), indicating that the data could be statistically combined. Pooling data from the 6 reports containing data on maternal cured meat intake of all types yielded an RR of 1.68 (1.30 2.17), being a statistically significant result. Analyzing CBT risk by type of cured meat ingested showed that hot dog consumption increased CBT risk by 33% (1.08 - 1.66), with a similar increase shown by frequent ingestion of sausage, i.e. 44%. Conclusion: The data provide support for the suspected causal association between ingestion of NOCs from cured meats during pregnancy and subsequent CBT in offspring. Limitations in study design preclude definitive conclusions, but the relationship warrants exploration via additional observational and laboratory-based studies. Copyright (C) 2004 S. Karger AG, Basel.