Use of Skeletal Muscle MRI in Diagnosis and Monitoring Disease Progression in Duchenne Muscular Dystrophy
Use of Skeletal Muscle MRI in Diagnosis and Monitoring Disease Progression in Duchenne Muscular Dystrophy
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DOI：
10.1016/j.pmr.2011.11.004
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发表时间：
2012-02-01
影响因子：
1.7
通讯作者：
Vandenborne, Krista
中科院分区：
文献类型：
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作者：
Finanger, Erika L.;Russman, Barry;Vandenborne, Krista
研究表明，使用磁共振成像（MRI）和磁共振波谱的各种方法来评估骨骼肌累及杜氏肌营养不良的前景。然而，这些研究主要是采用横断面设计进行的，这些MRI变化与疾病进展和疾病严重程度的相关性尚未完全阐明。总的来说，骨骼肌MRI是一种强大而敏感的肌肉疾病评估技术，其作为疾病进展或治疗反应的生物标志物在临床试验中的应用值得进一步研究。
Studies have shown promise in using various approaches of magnetic resonance imaging (MRI) and magnetic resonance spectroscopy to evaluate skeletal muscle involvement in Duchenne muscular dystrophy. However, these studies have mainly been performed using a cross-sectional design, and the correlation of these MRI changes with disease progression and disease severity has not been fully elucidated. Overall, skeletal muscle MRI is a powerful and sensitive technique in the evaluation of muscle disease, and its use as a biomarker for disease progression or therapeutic response in clinical trials deserves further study.