Normal human pregnancy is associated with an elevation in the immune suppressive CD25+ CD4+ regulatory T-cell subset
Normal human pregnancy is associated with an elevation in the immune suppressive CD25+ CD4+ regulatory T-cell subset
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DOI：
10.1111/j.1365-2567.2004.01869.x
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发表时间：
2004-05-01
期刊：
影响因子：
6.4
通讯作者：
Drayson, MT
中科院分区：
文献类型：
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作者：
Somerset, DA;Zheng, Y;Drayson, MT
CD4(+) CD25(+) T调节细胞（T- reg）抑制抗原特异性免疫反应，对同种异体移植物耐受很重要。在怀孕期间，母亲耐受表达父亲抗原的同种异体移植物（胎儿），需要在一段程序化的时间内对免疫调节进行实质性的改变。我们分析了免疫抑制性T-Reg细胞是否在怀孕期间发生改变，从而可能在这种耐受状态中发挥作用。采用流式细胞术检测25例非孕妇、63例孕妇和7例产后健康妇女血液中T-Reg细胞的存在。我们观察到循环T-Reg细胞在妊娠早期增加，在妊娠中期达到峰值，然后在产后下降。分离的CD25(+) CD4（+）细胞表达FoxP3信使RNA （T- reg细胞的标记物），并抑制自体CD4(+) CD25 T细胞对异体树突状细胞的增殖反应。这些数据支持了一个概念，即正常妊娠与T-Reg细胞数量的增加有关，这可能对维持母胎耐受性很重要。
CD4(+) CD25(+) T regulatory cells (T-Reg), suppress antigen-specific immune responses and are important for allograft tolerance. During pregnancy the mother tolerates an allograft expressing paternal antigens (the fetus) requiring substantial changes in immune regulation over a programmed period of time. We analysed whether immune-suppressive T-Reg cells were altered during pregnancy and therefore might play a part in this tolerant state. The presence of T-Reg cells was assessed in the blood of 25 non-pregnant, 63 pregnant and seven postnatal healthy women by flow cytometry. We observed an increase in circulating T-Reg cells during early pregnancy, peaking during the second trimester and then a decline postpartum. Isolated CD25(+) CD4(+) cells expressed FoxP3 messenger RNA, a marker of T-Reg cells, and suppressed proliferative responses of autologous CD4(+) CD25 T cells to allogeneic dendritic cells. These data support the concept that normal pregnancy is associated with an elevation in the number of T-Reg cells which may be important in maintaining materno-fetal tolerance.