Formulation and Evaluation of Verdant Tablets Containing Saponin-Coalesced Silver Nanoparticles Got from Fenugreek Seed Extract
Formulation and Evaluation of Verdant Tablets Containing Saponin-Coalesced Silver Nanoparticles Got from Fenugreek Seed Extract
复制标题
胡芦巴籽提取物皂苷聚结银纳米颗粒 Verdant 片剂的配制及评价
DOI：
10.3390/ecsoc-25-11765
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Bhavika Patil
中科院分区：
文献类型：
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作者：
J. Patil;Hamid Sayyed;H. Suryawanshi;Bhavika Patil
目前，由于几种应用，纳米颗粒的需求很大。商业上使用的金属纳米颗粒通常由合成化学品组成。这些化学品有毒且易燃。目前的研究的目的是探索使用草药材料的纳米颗粒的优点;因此，我们开发了胡芦巴（胡芦巴）种子的水提取物的银纳米颗粒，并将其配制成片剂。胡芦巴种子含有甾体皂甙元，可以降低血液胆固醇水平、控制糖尿病、增加母乳产量、帮助消化，并有助于减肥，因此在所有上述情况下都可以推荐制备的制剂。对制剂评价的预压缩参数为堆积密度、振实密度、卡尔指数、豪斯纳比和休止角，结果分别为0.16 gm/cc、0.86 gm/cc、14.16、比值1.13和32 μ m;而压缩后参数是重量变化、脆碎度、硬度、厚度和崩解度，结果为0.504克，0.2%，3.21gm/cm 2，2.55mm，7min。
: Presently, nanoparticles are in demand due to several applications. Commercially used metallic nanoparticles are usually comprised of synthetic chemicals. These chemicals are noxious and combustible. Current research had the objective to explore the advantages of nanoparticles using herbal material; hence, we developed silver nanoparticles of aqueous extract of Trigonellafoenum graecum (Fenugreek) seeds and formulated them into tablets. Fenugreek seeds contain steroidal sapogenins and are responsible for the reduction of blood cholesterol levels, control diabetes, enhance breast milk production, digestion aid, and helps in weight loss hence prepared formulation can be recommended in all the above cases. The pre-compression parameters evaluated for formulations are bulk density, tapped density, Carr’s index, Hausner’s ratio, and angle of repose, and the results are 0.16 gm/cc, 0.86 gm/cc, 14.16, ratio 1.13 and 32 ◦ , respectively; whereas post-compression parameters are weight variation, friability, hardness, thickness, and disintegration, and the results are 0.504 gm, 0.2%, 3.21 gm/cm 2 , 2.55 mm, and 7 min, respectively.