Comparison of oxaliplatin- and cisplatin-induced painful peripheral neuropathy in the rat.
Comparison of oxaliplatin- and cisplatin-induced painful peripheral neuropathy in the rat.
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DOI：
10.1016/j.jpain.2008.12.003
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发表时间：
2009-05
期刊：
影响因子：
--
通讯作者：
Levine JD
中科院分区：
文献类型：
--
作者：
Joseph EK;Levine JD
虽然基于铂的癌症化疗会产生疼痛性周围神经病变作为剂量限制性副作用，但此类药物产生的疼痛综合征存在重要差异。在大鼠中，顺铂诱导的痛觉过敏的发病潜伏期为 24-48 小时，在 72-96 小时达到最大，并且可被半胱天冬酶信号传导抑制剂减弱，但不会被线粒体电子传递链 (mETC) 和抗氧化剂抑制剂减弱。相比之下，奥沙利铂诱导的机械痛觉过敏在 5 分钟时就已出现，并在 20 分钟时达到峰值。虽然奥沙利铂痛觉过敏持续数周，但从第 10-15 天左右开始，其严重程度降低至较低的第二平台水平。奥沙利铂诱导的痛觉过敏快速发生的第一个平台期的特点是显着的冷异常性疼痛，与顺铂相反，mETC 抑制剂和抗氧化剂可减轻痛觉过敏，但 caspase 信号传导抑制剂则不会。然而后来的测试发现，在第二个平台期间，其特征是痛觉过敏较不强烈，无冷异常性疼痛，并且被 caspase 信号传导抑制剂、mETC 抑制剂和抗氧化剂减弱。
While platinum-based cancer chemotherapies produce painful peripheral neuropathy as dose-limiting side effects, there are important differences in the pain syndromes produced by members of this class of drugs. In the rat Cisplatin-induced hyperalgesia has latency to onset of 24–48 hrs, is maximal by 72–96 hrs and is attenuated by inhibitors of caspase signaling, but not by inhibitors of the mitochondrial electron transport chain (mETC) and anti-oxidants. In contrast, Oxaliplatin-induced mechanical hyperalgesia is already present by 5 min, peaks by 20 min. While Oxaliplatin hyperalgesia persists for weeks, starting around day 10–15 its severity decreases to a lower 2nd plateau level. The rapid onset 1st plateau in Oxaliplatin-induced hyperalgesia was characterized by prominent cold allodynia and in contrast to Cisplatin was attenuated by inhibitors of the mETC, and anti-oxidants but not inhibitors of caspase signaling. However tested later, during the 2nd plateau was characterized by less intense hyperalgesia, no cold allodynia and was attenuated by inhibitors of caspase signaling, as well as by inhibitors of the mETC and by anti-oxidants.
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影响因子：
11.2
作者：
Heaney ML;Gardner JR;Karasavvas N;Golde DW;Scheinberg DA;Smith EA;O'Connor OA
通讯作者：
O'Connor OA
影响因子：
3.9
作者：
CADENAS, E;BOVERIS, A;STOPPANI, AOM
通讯作者：
STOPPANI, AOM
影响因子：
3.4
作者：
EASTMAN A
通讯作者：
EASTMAN A
影响因子：
4.1
作者：
Garrido, Nuria;Perez-Martos, Acisclo;Antonio Enriquez, Jose
通讯作者：
Antonio Enriquez, Jose
影响因子：
5
作者：
Adelsberger, H;Quasthoff, S;Lersch, C
通讯作者：
Lersch, C