Exercise-Induced Increases in Insulin Sensitivity After Bariatric Surgery Are Mediated By Muscle Extracellular Matrix Remodeling
Exercise-Induced Increases in Insulin Sensitivity After Bariatric Surgery Are Mediated By Muscle Extracellular Matrix Remodeling
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DOI：
10.2337/db19-1180
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发表时间：
2020-08-01
期刊：
影响因子：
7.7
通讯作者：
Gualano, Bruno
中科院分区：
文献类型：
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作者：
Dantas, Wagner S.;Roschel, Hamilton;Gualano, Bruno
运动似乎可以增强减肥（Roux-en-Y 胃绕道手术 [RYGB]）手术对胰岛素抵抗的有益效果。我们假设骨骼肌细胞外基质（ECM）重塑可能是这些益处的基础。女性被随机分配接受 RYGB（RYGB + ET）或标准护理（RYGB）后的有氧运动和阻力运动相结合的训练计划。通过口服葡萄糖耐量试验评估胰岛素敏感性。在基线以及术后 3 个月和 9 个月时获取肌肉活检标本，并进行全面的表型分析、转录组分析、分子途径鉴定和体外验证。运动训练比单纯手术改善胰岛素敏感性（例如，松田指数：RYGB 123% 对比 RYGB + ET 325%；P
Exercise seems to enhance the beneficial effect of bariatric (Roux-en-Y gastric bypass [RYGB]) surgery on insulin resistance. We hypothesized that skeletal muscle extracellular matrix (ECM) remodeling may underlie these benefits. Women were randomized to either a combined aerobic and resistance exercise training program following RYGB (RYGB + ET) or standard of care (RYGB). Insulin sensitivity was assessed by oral glucose tolerance test. Muscle biopsy specimens were obtained at baseline and 3 and 9 months after surgery and subjected to comprehensive phenotyping, transcriptome profiling, molecular pathway identification, and validation in vitro. Exercise training improved insulin sensitivity beyond surgery alone (e.g., Matsuda index: RYGB 123% vs. RYGB + ET 325%;P