[Intravenous 3-day Helicobacter pylori eradication therapy is highly effective in patients with bleeding peptic ulcer].
[Intravenous 3-day Helicobacter pylori eradication therapy is highly effective in patients with bleeding peptic ulcer].
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发表时间：
2002
影响因子：
1.9
通讯作者：
F. Ruíz Gómez;F. J. Sánchez Serrano;A. Martínez Egea;G. García del Castillo;J. S. Sãnchez Cuenca;M. Coronas Planas
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文献类型：
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作者：
F. Ruíz Gómez;F. J. Sánchez Serrano;A. Martínez Egea;G. García del Castillo;J. S. Sãnchez Cuenca;M. Coronas Planas
目的评价静脉内根除幽门螺杆菌3天疗法治疗幽门螺杆菌相关性消化性溃疡出血的疗效。幽门感染材料与方法我们研究了53例因消化性溃疡和尿素酶试验阳性而住院的上消化道出血患者，为期12个月。内镜诊断后，静脉注射泮托拉唑（40 mg/12小时）、甲硝唑（500 mg/8小时）和阿莫西林-克拉维酸（1，000 mg/200 mg/8小时）72小时。治疗结束后至少2个月通过13 C-尿素呼气试验评价根除治疗的疗效。结果51例患者纳入研究。其中，40人患有十二指肠溃疡，11人患有胃溃疡。H. 87.5%的十二指肠溃疡患者和63.6%的胃溃疡患者实现了幽门根除（p = 0.066）。未发现不良反应或出血复发，无患者退出治疗。结论：本研究中使用的超短程根除疗法是高效的。它的功效类似于口服治疗，并且避免了某些问题，例如不良反应和坚持治疗。
AIMS To evaluate the efficacy of 3-day intravenous Helicobacter pylori eradication therapy in patients with bleeding peptic ulcer associated with H. pylori infection. MATERIAL AND METHOD We studied 53 patients admitted to hospital with bleeding of the upper gastrointestinal tract due to peptic ulcer and positive urease test over a 12-month period. After endoscopic diagnosis, intravenous pantoprazole (40 mg/12 hours), metronidazole (500 mg/8 hours) and amoxicillin-clavulanic acid (1,000 mg/200 mg/8 hours) was administered for 72 hours. The efficacy of eradication therapy was evaluated by 13C-urea breath test at least 2 months after the end of treatment. RESULTS Fifty-one patients were included. Of these, 40 had duodenal ulcer and 11 had gastric ulcer. H. pylori eradication was achieved in 87.5% of those with duodenal ulcers and in 63.6% of those with gastric ulcers (p = 0.066). No adverse reactions or episodes of bleeding recurrence were found and none of the patients withdrew from treatment. CONCLUSIONS The ultra-short course eradication therapy used in this study is highly effective. Its efficacy is similar to that of oral treatment and it avoids certain problems such as adverse effects and adherence to treatment.