Chemokine receptor allelic polymorphisms: relationships to HIV resistance and disease progression.
Chemokine receptor allelic polymorphisms: relationships to HIV resistance and disease progression.
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趋化因子受体等位基因多态性：与艾滋病毒耐药性和疾病进展的关系。
DOI：
10.1006/smim.1998.0132
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Kang,S
中科院分区：
文献类型：
--
作者：
Paxton,WA;Kang,S
现在已经确定，一系列 CC 和 CXC 趋化因子受体与 CD4 分子结合，可以与 HIV-1 gp120 蛋白相互作用，促进病毒融合。 CC趋化因子受体CCR5（主要的M向性病毒辅助受体）中的32bp缺失可提供相当大的保护以防止HIV-1传播，并与疾病进展的延迟相关。 Δ32 等位基因的作用似乎是通过 CCR5 表达的表型而不是基因型介导的。在这里，我们讨论趋化因子受体库中的 Δ32 等位基因和其他多态性可能对 HIV-1 传播和疾病进展产生的潜在影响。
It is now well established that an array of CC and CXC chemokine receptors, in association with the CD4 molecule, can interact with the HIV-1 gp120 protein to facilitate viral fusion. A 32bp deletion in the CC chemokine receptor CCR5, the major M-tropic viral co-receptor, provides considerable protection against HIV-1 transmission and has been associated with a delay in disease progression. The effects of the Δ32 allele appear to be mediated through the phenotype of CCR5 expression as opposed to genotype. Here we discuss the potential effects that the Δ32 allele and other polymorphisms in the chemokine receptor repertoire may have on both HIV-1 transmission and disease progression.