INDIVIDUAL ADMIXTURE ESTIMATES - DISEASE ASSOCIATIONS AND INDIVIDUAL RISK OF DIABETES AND GALLBLADDER-DISEASE AMONG MEXICAN-AMERICANS IN STARR COUNTY, TEXAS
INDIVIDUAL ADMIXTURE ESTIMATES - DISEASE ASSOCIATIONS AND INDIVIDUAL RISK OF DIABETES AND GALLBLADDER-DISEASE AMONG MEXICAN-AMERICANS IN STARR COUNTY, TEXAS
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DOI：
10.1002/ajpa.1330700404
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发表时间：
1986-08-01
影响因子：
2.8
通讯作者：
SCHULL, WJ
中科院分区：
文献类型：
--
作者：
HANIS, CL;CHAKRABORTY, R;SCHULL, WJ
几种常见慢性病的种族和地理分布显示出与基因和遗传混合物分布一致的独特模式。例如，糖尿病和胆囊疾病在美洲印第安人中发生率最高，而那些与他们基因混合的人（如墨西哥裔美国人）的发病率居中，白人和黑人的发病率最低。由于混合群体中个体间的祖先亲和力存在异质性，本文提出了一种估计个体混合概率的方法。结果证实，在得克萨斯州斯塔尔县的墨西哥裔美国人中，个体混合物存在很大的异质性，平均值表明该人群中65%的基因是高加索人衍生的，35%是美洲印第安人衍生的。个人估计被证明是无关的糖尿病的概率，只有轻微的胆囊疾病，与那些最美洲印第安人的亲和力是在增加的风险。这些结果是基因座独立分类的结果，并且表明除非所用的标记物与感兴趣的疾病相关（包括连锁），否则该方法将具有有限的实用性。然而，个体混合物的估计值对于检验群体结构的各个方面是有用的，并且随着越来越多的基因组由标记代表，个体混合物的估计值对于预测疾病和检验疾病相关性将发现更大的效用，这是一个非常有可能的前景，其中DNA多态性的丰度被限制性酶鉴定。
The ethnic and geographic distributions of several common chronic disease show distinct patterns that are consistent with the distribution of genes and genetic admixture. For example, diabetes and gallbladder disease occur most frequently among Amerindians, while those genetically admixed with them (such as Mexican-Americans) have intermediate rates, and lowest rates are found among Whites and Blacks. Because there will be heterogeneity from individual to individual in ancestral affinity within an admixed population, a method is developed for estimating each person''s admixture probability. Results confirm that there is substantial heterogeneity of individual admixture among Mexican-Americans in Starr County, Texas, with a mean value indicating that 65% of genes in this population are Caucasian derived and 35% Amerindian derived. The individual estimates are shown to be unrelated to the probability of being diabetic and only marginally related to gallbladder disease, with those having the most Amerindian affinity being at increased risk. These results are a consequence of the independent assortment of loci and indicate that unless the markers employed are related (including linkage) to the disease of interest, the method will have limited utility. Individual admixture estimates will be useful, however, for examining aspects of population structure and will find increased utility for predicting disease and examining disease associations as more and more of the genome is represented by markers, a very probable prospect with the abundance of DNA polymorphism being identified by restriction enzymes.