Risk factors and cognitive correlates of white matter hyperintensities in ethnically diverse populations without dementia: the COSMIC consortium.
Risk factors and cognitive correlates of white matter hyperintensities in ethnically diverse populations without dementia: the COSMIC consortium.
复制标题
无痴呆的不同种族人群白质高信号的危险因素和认知相关性：COSMIC 联盟。
DOI：
10.1101/2023.08.30.23294876
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Anstey,Kaarin
中科院分区：
文献类型：
--
作者：
Lin,Keshuo;Wen,Wei;Lipnicki,DarrenM;Mewton,Louise;Chen,Rory;Du,Jing;Wang,Dadong;Skoog,Ingmar;Sterner,ThereseRydberg;Najar,Jenna;Kim,KiWoong;Han,JiWon;Kim,JunSung;Ng,TzePin;Ho,Roger;Chua,DeniseQianLing;Anstey,Kaarin
白质高强度(WMH)是脑部小血管疾病的重要影像指标，但在不同种族和/或不同地理区域的人群中，白质高强度(WMH)与血管危险因素和认知功能的相关性还没有很好的文献记载。方法我们使用来自澳大利亚、新加坡、韩国和瑞典(N=1946)的5个基于人群的非痴呆老年人队列数据，研究了WMH与血管危险因素和认知的关系。用UBO探测器测量WMH体积(全脑、脑室周围和深层)，并使用战斗模型进行协调。我们还协调了全球认知和个人认知域的各种血管风险因素和得分。结果与较大的全脑WMH体积相关的因素包括糖尿病、高血压、中风、当前吸烟、体重指数、较高的酒精摄入量和体力活动不足。与亚洲人相比，白人的高血压和中风与WMH量有更强的相关性。经多次测试校正后，未发现白质血量与认知能力之间的相关性。结论本研究强调了血管危险因素对白质血量贡献的种族差异。
INTRODUCTIONWhite matter hyperintensities (WMHs) are an important imaging marker for cerebral small vessel diseases, but their risk factors and cognitive associations have not been well documented in populations of different ethnicities and/or from different geographical regions.METHODSWe investigated how WMHs were associated with vascular risk factors and cognition in both Whites and Asians, using data from five population‐based cohorts of non‐demented older individuals from Australia, Singapore, South Korea, and Sweden (N= 1946). WMH volumes (whole brain, periventricular, and deep) were quantified with UBO Detector and harmonized using the ComBat model. We also harmonized various vascular risk factors and scores for global cognition and individual cognitive domains.RESULTSFactors associated with larger whole brain WMH volumes included diabetes, hypertension, stroke, current smoking, body mass index, higher alcohol intake, and insufficient physical activity. Hypertension and stroke had stronger associations with WMH volumes in Whites than in Asians. No associations between WMH volumes and cognitive performance were found after correction for multiple testing.CONCLUSIONThe current study highlights ethnic differences in the contributions of vascular risk factors to WMHs.