EFFECTS OF ETHANOL ON THE GASTRIC MUCOSA
EFFECTS OF ETHANOL ON THE GASTRIC MUCOSA
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DOI：
10.1159/000171159
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发表时间：
1987-01-01
影响因子：
2.3
通讯作者：
GUSLANDI M
中科院分区：
文献类型：
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作者：
GUSLANDI M
酒精对胃粘膜产生损伤作用的概念并不新鲜，可以追溯到博蒙[1]的观察。在动物研究中，乙醇浓度高于20%会导致多发性胃糜烂，其发生率、数量和严重程度随乙醇浓度增加而增加[2]。通过光学显微镜和电子显微镜观察，20-40%乙醇似乎会导致顶端细胞膜进行性破裂和细胞脱落，并在几分钟内暴露固有层[3]。粘蛋白和蛋白质挤出到管腔[3]和组胺释放[4，5]也发生。尽管上皮细胞明显分离，但细胞间紧密连接似乎保持完整[3]。大鼠急性给予无水乙醇也会导致溶酶体膜不稳定，释放各种酶，包括酸性磷酸酶[6，7]，这反过来可能加剧粘膜损伤[6]，100%乙醇与胃粘膜接触，引起粘膜表面广泛坏死，在几分钟内，粘膜增殖细胞严重受损，
The concept that alcohol exerts damaging effects on the gastric mucosa is not new and can be traced back to Beaumont’s [1] obser vations. In animal studies concentrations of ethanol higher than 20% were shown to in duce multiple gastric erosions, the incidence, the number and the severity of which in crease as a function of alcohol concentration [2]. By light and electron microscopy 20-40% ethanol appears to cause progressive disruption of apical cell membrane and cel lular exfoliation with exposure of the lamina propria within a few minutes [3]. Extrusion of mucin and protein into the lumen [3] and histamine release [4, 5] also take place. De spite an evident separation of epithelial cells, intercellular tight junctions seem to remain intact [3].Acute administration of absolute ethanol in rats also results in the labilization of the lysosomal membrane with release of various enzymes, including acid phosphatase [6, 7], which in turn may exacerbate mucosal inju ries [6], Contact between 100% ethanol and the gastric mucosa induces extensive necro sis of mucosal surface and, in a few minutes, severe damage of the mucosal proliferative