PLEURAL FLUID TO SERUM BILIRUBIN CONCENTRATION RATIO FOR THE SEPARATION OF TRANSUDATES FROM EXUDATES
PLEURAL FLUID TO SERUM BILIRUBIN CONCENTRATION RATIO FOR THE SEPARATION OF TRANSUDATES FROM EXUDATES
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DOI：
10.1378/chest.98.1.141
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发表时间：
1990-07-01
期刊：
影响因子：
9.6
通讯作者：
ROSENTHAL, T
中科院分区：
文献类型：
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作者：
MEISEL, S;SHAMISS, A;ROSENTHAL, T
胸膜腔内积聚的液体是漏出液还是渗出液，由胸膜液与血清 LDH 和蛋白质浓度比的广泛使用的标准确定。这种区别对于限制这种情况的可能原因的鉴别诊断范围很重要。我们发现胸水与血清总胆红素的比率可以达到相同的目的。根据既定标准确定，胆红素浓度比为 0.6 或更高与存在渗出物的相关性具有统计学上的高度显着性；其敏感性、特异性、阳性预测准确性以及与病因学和 LDH 或蛋白质标准（Light 标准）相关的总体准确性约为 90%。因此，胆红素标准在统计学上等同于广泛接受的 LDH 和蛋白质标准。
Whether fluid accumulating in the pleural space is a transudate or an exudate is determined by the widely used criteria of the pleural fluid to serum LDH and protein concentration ratios. Such a distinction is important for limiting the extent of the differential diagnosis of possible causes for this condition. We have found that a pleural fluid to serum total bilirubin ratio can serve the same purpose. The correlation of a bilirubin concentration ratio of 0.6 or more with the presence of an exudate as determined by established criteria is statistically highly significant; and its sensitivity, specificity positive predictive accuracy, and overall accuracy in relation to etiology and LDH or protein criteria (Light''s criteria) are about 90 percent. Hence, the bilirubin criterion is statistically equivalent to the widely accepted LDH and protein criteria.