Strong Maternal Khoisan Contribution to the South African Coloured Population: A Case of Gender-Biased Admixture
Strong Maternal Khoisan Contribution to the South African Coloured Population: A Case of Gender-Biased Admixture
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DOI：
10.1016/j.ajhg.2010.02.014
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发表时间：
2010-04-09
影响因子：
9.8
通讯作者：
Behar, Doron M.
中科院分区：
文献类型：
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作者：
Quintana-Murci, Lluis;Harmant, Christine;Behar, Doron M.
对最近混合人群的研究提供了独特的工具，用于通过混合图谱了解最近的人口动态、与新兴人口建立相关的社会文化因素以及疾病的遗传基础。历史记录和最近的常染色体数据表明，南非有色人种形成了一个独特的高度混合的群体，这是来自非洲、欧洲和亚洲不同民族的相遇的结果。然而，人们对这个混合群体最近建立的模式知之甚少。在这里，我们通过线粒体的详细系统发育地理学分析来展示！大量南非有色人种样本中的 DNA 和 Y 染色体变异表明，该群体源自至少五个不同的父辈群体（科伊桑人、班图斯人、欧洲人、印度人和东南亚人），他们对南非有色人种的基础做出了不同的贡献。此外，我们的分析揭示了不同人群遗传成分的性别贡献极不平衡，最引人注目的是科伊桑人的巨大母性贡献（超过60%），而欧洲人的母性贡献相对于其父系同胞几乎可以忽略不计。这项研究中描述的性别偏见混合的总体情况表明，现代南非有色人种主要是由于大约 350 年前欧洲和非洲男性与好望角本土科伊桑女性的早期相遇。
The study of recently admixed populations provides unique tools for understanding recent population dynamics, socio-cultural factors associated with the founding of emerging populations, and the genetic basis of disease by means of admixture mapping. Historical records and recent autosomal data indicate that the South African Coloured population forms a unique highly admixed population, resulting from the encounter of different peoples from Africa, Europe, and Asia. However, little is known about the mode by which this admixed population was recently founded. Here we show, through detailed phylogeographic analyses of mitochondria! DNA and Y-chromosome variation in a large sample of South African Coloured individuals, that this population derives from at least five different parental populations (Khoisan, Bantus, Europeans, Indians, and Southeast Asians), who have differently contributed to the foundation of the South African Coloured. In addition, our analyses reveal extraordinarily unbalanced gender-specific contributions of the various population genetic components, the most striking being the massive maternal contribution of Khoisan peoples (more than 60%) and the almost negligible maternal contribution of Europeans with respect to their paternal counterparts. The overall picture of gender-biased admixture depicted in this study indicates that the modern South African Coloured population results mainly from the early encounter of European and African males with autochthonous Khoisan females of the Cape of Good Hope around 350 years ago.