Wearable salivary uric acid mouthguard biosensor with integrated wireless electronics.
Wearable salivary uric acid mouthguard biosensor with integrated wireless electronics.
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DOI：
10.1016/j.bios.2015.07.039
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发表时间：
2015-12-15
影响因子：
12.6
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Kim J;Imani S;de Araujo WR;Warchall J;Valdés-Ramírez G;Paixão TR;Mercier PP;Wang J
本文演示了一种能够无创监测唾液尿酸（SUA）水平的仪器护齿器。酶（尿酸酶）修饰的丝网印刷电极系统已经集成到一个护齿平台上，连同解剖学小型化的仪器电子设备，包括恒电位器、微控制器和低功耗蓝牙（BLE）收发器。基于rfid的生物传感系统需要大量近端电源，与之不同的是，开发的平台能够将传感信息实时无线传输到标准智能手机、笔记本电脑和其他消费电子产品，用于按需处理、诊断或存储。该护齿生物传感器系统对人体唾液中尿酸的检测具有高灵敏度、选择性和稳定性，涵盖了健康人群和高尿酸血症患者的浓度范围。新的无线护齿生物传感器系统能够实时和连续地监测SUA水平，并且可以很容易地扩展到不同分析物的传感器阵列，从而为各种健康和健身应用提供有吸引力的可穿戴监测系统。
This article demonstrates an instrumented mouthguard capable of non-invasively monitoring salivary uric acid (SUA) levels. The enzyme (uricase)-modified screen printed electrode system has been integrated onto a mouthguard platform along with anatomically-miniaturized instrumentation electronics featuring a potentiostat, microcontroller, and a Bluetooth Low Energy (BLE) transceiver. Unlike RFID-based biosensing systems, which require large proximal power sources, the developed platform enables real-time wireless transmission of the sensed information to standard smartphones, laptops, and other consumer electronics for on-demand processing, diagnostics, or storage. The mouthguard biosensor system offers high sensitivity, selectivity, and stability towards uric acid detection in human saliva, covering the concentration ranges for both healthy people and hyperuricemia patients. The new wireless mouthguard biosensor system is able to monitor SUA level in real-time and continuous fashion, and can be readily expanded to an array of sensors for different analytes to enable an attractive wearable monitoring system for diverse health and fitness applications.