Fibroblasts in cancer dormancy: foe or friend?

Fibroblasts in cancer dormancy: foe or friend?
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DOI:
10.1186/s12935-021-01883-2
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发表时间:
2021-03-26
影响因子:
5.8
通讯作者:
Liang XH
Liang XH
中科院分区:
医学2区
文献类型:
--
作者:
Dai L;Li M;Zhang WL;Tang YJ;Tang YL;Liang XH

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Cancer dormancy is defined that the residual cancer cells could enter into a state of quiescence and patients remain asymptomatic for years or even decades after anti-tumor therapies. Fibroblasts, which represent a predominant cell type in tumor microenvironment, play a pivotal role in determining the ultimate fate of tumor cells. This review recapitulates the pleiotropic roles of fibroblasts which are divided into normal, senescent, cancer-associated fibroblasts (CAFs) and circulation CAFs in tumor dormancy, relapse, metastasis and resistance to therapy to help the treatment of cancer metastasis.
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