Dynamic contrast-enhanced MRI and MR diffusion imaging to distinguish between glandular and stromal prostatic tissues
Dynamic contrast-enhanced MRI and MR diffusion imaging to distinguish between glandular and stromal prostatic tissues
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DOI：
10.1016/j.mri.2008.01.033
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发表时间：
2008-10-01
影响因子：
2.5
通讯作者：
Kurhanewicz, John
中科院分区：
文献类型：
--
作者：
Noworolski, Susan Moyher;Vigneron, Daniel B.;Kurhanewicz, John
目的：比较动态对比增强（DCE）磁共振成像（MRI）的峰值增强（PE）和磁共振（MR）的方向平均表观扩散系数（< D >）在腺体与间质前列腺组织中的差异，并通过该比较推断钆-DTPA（Gd-DTPA）不进入健康腺体或导管的假设是否合理。材料和方法：对17例未经治疗的疑似或确诊前列腺癌受试者进行了MRI、MR波谱成像、DCE MRI和MR弥散成像评价。结果< D >：与间质前列腺组织相比，腺导管组织的PE较低[125 +/- 6.4（%基线）]，较高[1.57 +/-0.15（S/10（-3）mm（2））]，而与间质前列腺组织相比，腺导管组织的PE较低[125 +/- 6.4（%基线）]，较高< D >[1.57 +/- 0.15（S/10（-3）mm（2））]。低位导管组织[PE=132 +/- 5.5（%基线）（P=1.18 +/- 0.20（s/10（-3）mm（2））（P（s/10（-3）mm（2）-10.7xPE（1/%），R-2=1.0，P先前已在前列腺癌与健康组织中报告。(C)2008年爱思唯尔公司All rights reserved.
Purpose: To compare peak enhancement (PE), determined from dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and the magnetic resonance (MR) directionally-averaged apparent diffusion coefficient (< D >) in glandular versus stromal prostatic tissues and, with this comparison, to infer if the hypothesis that gadolinium-DTPA (Gd-DTPA) does not enter healthy glands or ducts is plausible.Materials and Methods: MRI, MR spectroscopic imaging, DCE MRI and MR diffusion were evaluated in 17 untreated subjects with suspected or proven prostate cancer. PE and < D > were compared in glandular-ductal tissues [normal peripheral zone and glandular benign prostatic hyperplasia (BPH)] and stromal-low ductal tissues (central gland/mixed BPH and stromal BPH).Results: The glandular-ductal tissues had lower PE [125 +/- 6.4 (% baseline)] and higher < D > [1.57 +/- 0.15 (S/10(-3) mm(2))] than the stromal-low ductal tissues [PE=132 +/- 5.5 (% baseline) (P=1.18 +/- 0.20 (s/10(-3) mm(2)) (P(s/10(-3) mm(2))-10.7xPE (1/%), R-2=1.0 and P that previously have been reported in prostate cancer versus healthy tissue. (C) 2008 Elsevier Inc. All rights reserved.