Transcriptional profile of Marek's disease virus genes in chicken thymus during different phases of MDV infection
Transcriptional profile of Marek's disease virus genes in chicken thymus during different phases of MDV infection
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MDV感染不同时期鸡胸腺中马立克氏病病毒基因的转录谱
DOI：
10.1007/s00705-013-1665-z
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发表时间：
2013-08-01
影响因子：
2.7
通讯作者：
Shao, Hongxia
中科院分区：
文献类型：
--
作者：
Hu, Xuming;Qin, Aijian;Shao, Hongxia
在这项研究中，在感染 RB1B 株的鸡胸腺中检测到 86 个马立克氏病病毒 (MDV) 转录本。其中 47 个主要参与病毒复制和免疫逃逸，在感染后 7 天 (dpi) 时检测到。大多数基因的表达在 21 和 28 dpi 时增加，但在 14 dpi 时减少或关闭。与其他组织不同，我们发现受感染的胸腺在 14 dpi 时就建立了潜伏感染。在这里，我们展示了 MDV 转录本的表达动力学及其在受感染胸腺中的相对表达。
In this study, 86 Marek's disease virus (MDV) transcripts were detected in chicken thymus infected with RB1B strain. Forty-seven of them, which were mainly involved in viral replication and immune escape, were detected at 7 days postinfection (dpi). Expression of most of the genes was increased at 21 and 28 dpi but reduced or shut down at 14 dpi. Unlike others tissues, we found that a latent infection was established at 14 dpi in infected thymus. Here, we show the kinetics of expression of MDV transcripts and their relative expression in infected thymus.