Sulcogyral pattern and sulcal count of the orbitofrontal cortex in individuals at ultra high risk for psychosis
Sulcogyral pattern and sulcal count of the orbitofrontal cortex in individuals at ultra high risk for psychosis
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DOI：
10.1016/j.schres.2014.02.008
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发表时间：
2014-04-01
影响因子：
4.5
通讯作者：
Wood, Stephen J.
中科院分区：
文献类型：
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作者：
Lavoie, Suzie;Bartholomeuz, Cali F.;Wood, Stephen J.
在普通人群中已鉴定出三种类型的眶前叶皮质沟回类型。这三种类型的分布已被发现在具有精神病遗传风险的个人以及首发精神病(FEP)和慢性精神分裂症患者中发生改变。这项研究的目的是确定OFC沟回模式的改变是否存在于一大批有超高精神病风险(UHR)的个体。对OFC分型，计数OFC表面存在的后沟和中间沟的数目。比较了对照组(n=58)和UHR转化组(n=49)与未转化组(n=77)的脑沟回类型和数量。最后，探讨了脑沟类型和脑沟数目与智商、症状严重程度和社会功能的关系。与在慢性精神分裂症和FEP中进行的其他研究一致，后来转变为精神病的UHR个体显示，与对照组相比，右侧大脑半球I型OFC的发生率较低(X(2)=19.847，p<；0.001)。这些高度一致的结果表明，在右脑拥有I型OFC具有保护作用。此外，OFC脑沟计数显示，与UHR组相比，对照组的后脑(右半球；chi(2)=11.658，p=0.003)和中间沟(左：chi(2)=6.643，p=0.036；右：chi(2)=11.726，p=0.020)的数量更多。然而，未观察到OFC类型或脑沟计数与智商、症状和功能之间的关系。(C)2014爱思唯尔B.V.保留所有权利。
Three types of orbitofrontal cortex (OFC) sulcogyral patterns have been identified in the general population. The distribution of these three types has been found to be altered in individuals at genetic risk of psychosis, and in patients with first episode psychosis (FEP) and chronic schizophrenia. This study aims at establishing whether altered OFC sulcogyral patterns were present in a large cohort of individuals at ultra high risk (UHR) for psychosis. OFC pattern type was classified and the number of posterior and intermediate sulci present on the surface of the OFC was counted. OFC sulcogyral type and the number of sulci were compared between controls (n = 58) and UHR participants who transitioned (n = 49) versus those who did not transition (n = 77) to psychosis. Finally, the relationship between sulcogyral type and number of sulci with intellectual quotient (IQ), symptom severity and social functioning of UHR individuals was explored. In line with other studies conducted in chronic schizophrenia and FEP, UHR individuals who later transitioned to psychosis showed a reduced incidence of the Type I OFC on the right hemisphere compared to controls (chi(2) = 19.847, p < 0.001). These highly consistent results point towards the protective effect of possessing a Type I OFC in the right hemisphere. Furthermore, OFC sulcus counts revealed that controls presented with a higher number of posterior (right hemisphere; chi(2) = 11.658, p = 0.003) and intermediate sulci (left: chi(2) = 6.643, p = 0.036; right: chi(2) = 11.726, p = 0.020) when compared to UHR individuals. However, no associations between OFC types or sulcus count and IQ, symptoms and functioning were observed. (C) 2014 Elsevier B. V. All rights reserved.