Acoustic holograms for directing arbitrary cavitation patterns
Acoustic holograms for directing arbitrary cavitation patterns
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DOI：
10.1063/5.0035298
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发表时间：
2021-02-01
影响因子：
4
通讯作者：
Dayton, Paul A.
中科院分区：
文献类型：
--
作者：
Kim, Jinwook;Kasoji, Sandeep;Dayton, Paul A.
空化是生物医学声学中的一种重要现象。它可以产生两种期望的结果（即，体内局部治疗效果）和不希望的结果（即，组织损伤），因此理解和引导空化场都是重要的。通过使用三维打印的声透镜和空化敏感的声幻影，我们证明了任意形状的二维（2D）微泡空化场的产生。在这项研究中，我们展示了在目标平面上将1MHz声束成形为字符“7”，该目标平面包含比明胶体模中封装微泡的空化阈值更高的机械指数。首先通过使用角谱方法计算期望场的相位图来设计透镜图案。在实施透镜之后，通过透镜的声脉冲在体模中产生目标声场，并产生遵循预期2D图案的空化图。空泡模式与激发束的声压图相似（结构相似性为0.476）。
Cavitation is an important phenomenon in biomedical acoustics. It can produce both desired outcomes (i.e., local therapeutic effects in vivo) and undesired outcomes (i.e., tissue damage), and it is, thus, important to both understand and direct cavitation fields. Through the use of three-dimensional-printed acoustic lenses and cavitation-sensitive acoustic phantoms, we demonstrate the generation of arbitrary shape two-dimensional (2D) microbubble cavitation fields. In this study, we demonstrate shaping a 1MHz acoustic beam as the character "7" on a target plane that contains a higher mechanical index than the cavitation threshold for encapsulated microbubbles in a gelatin phantom. The lens pattern is first designed by calculating the phase map of the desired field using an angular spectrum approach. After lens implementation, acoustic pulsing through the lens generated the target acoustic field in a phantom and produced a cavitation map following the intended 2D pattern. The cavitation pattern was similar (with the structural similarity of 0.476) to the acoustic pressure map of the excitation beam.